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Symbol
Name
ID 		Tgfbr2
transforming growth factor, beta receptor II
MGI:98729
Phenotype annotations related to hematopoietic system
Darker colors indicate more annotations
Human Phenotypes
Gastrointestinal hemorrhage
Leukemia
Hematological neoplasm
Lymphoma
Non-Hodgkin lymphoma
T-cell lymphoma
Hepatosplenomegaly
Disease(s) Associated with TGFBR2
Lynch syndrome
mismatch repair cancer syndrome
pancreatic cancer

Mouse Phenotypes
increased T cell proliferation
abnormal embryonic hematopoiesis
small thymus
enlarged spleen
abnormal erythropoiesis
decreased Langerhans cell number
absent plasma cells
increased memory T cell number
increased regulatory T cell number
increased leukocyte cell number
abnormal B-1 B cell morphology
abnormal B-1 B cell number
abnormal CD8-positive, alpha beta T cell morphology
microgliosis
abnormal B cell physiology
decreased IgA level
increased IgG level
increased IgM level
abnormal T cell activation
Availability Mouse Genotype
Tgfbr2tm1.1Karl/Tgfbr2tm1.1Karl
Tgfbr2tm1Mmt/Tgfbr2tm1Mmt
Tg(CD2-Tgfbr2)1Grs/0
Tg(CD2-Tgfbr2)1Grs/?
Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm
Tg(CD207-cre)1Dhka/?  (conditional)
Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm
Tg(Cd4-cre)1Cwi/0  (conditional)
Tg(CAG-cre/Esr1*)5Amc/0
Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm  (conditional)
Tgfbr2tm1Karl/Tgfbr2tm1Karl
Tg(Mx1-cre)1Cgn/0  (conditional)
Tgfbr2tm1Karl/Tgfbr2tm1Karl
H2az2Tg(Wnt1-cre)11Rth/H2az2+  (conditional)
Cd4tm1(cre/ERT2)Thbu/Cd4+
Tgfbr2tm1Karl/Tgfbr2tm1Karl  (conditional)
Cd19tm1(cre)Cgn/Cd19+
Tgfbr2tm1Roes/Tgfbr2tm1Roes  (conditional)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/14/2024
MGI 6.23 		The Jackson Laboratory