Symbol
Name
ID

Tcf3
transcription factor 3
MGI:98510

Phenotype annotations related to hematopoietic system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes

Decreased circulating IgA level

Decreased circulating IgE

Decreased circulating IgG level

Decreased circulating total IgM

Agammaglobulinemia

Partial absence of specific antibody response to tetanus vaccine

Pancytopenia

Anemia

B lymphocytopenia

Decreased proportion of CD8-positive, alpha-beta TEMRA T cells

Increased proportion of effector memory CD8-positive, alpha-beta T cells

B Acute Lymphoblastic Leukemia

Splenomegaly

Disease(s) Associated with TCF3

agammaglobulinemia 8A

agammaglobulinemia 8B

Mouse Phenotypes

hematopoietic system phenotype

enlarged thymus

thymus hypoplasia

abnormal hematopoietic system morphology/development

abnormal blood cell morphology/development

abnormal lymphopoiesis

abnormal B cell differentiation

decreased immature B cell number

decreased transitional stage B cell number

abnormal immunoglobulin V(D)J recombination

abnormal immunoglobulin heavy chain V(D)J recombination

abnormal immunoglobulin light chain V-J recombination

decreased pro-B cell number

absent pro-B cells

arrested B cell differentiation

increased double-negative T cell number

decreased double-positive T cell number

decreased dendritic cell number

abnormal lymphocyte cell number

abnormal B cell number

decreased germinal center B cell number

decreased mature B cell number

increased marginal zone B cell number

decreased B cell number

absent B cells

decreased pre-B cell number

absent pre-B cells

increased B cell number

decreased NK cell number

abnormal T cell subpopulation ratio

increased single-positive T cell number

decreased lymphocyte cell number

abnormal hematopoietic stem cell morphology

abnormal germinal center B cell morphology

spleen atrophy

Availability

Mouse Genotype

Tcf3^tm1Cmu/Tcf3^tm1Cmu

Tcf3^tm1Wein/Tcf3^tm1Wein

Tcf3^tm1Xhsu/Tcf3^tm1Xhsu

Tcf3^tm1Zhu/Tcf3^tm1Zhu

Tcf3^tm2Cmu/Tcf3^tm2Cmu

Tcf3^tm2Wein/Tcf3^tm2Wein

Tcf3^tm2Zhu/Tcf3^tm2Zhu

Tcf3^tm3.1Cmu/Tcf3^tm3.1Cmu

Tcf3^tm3Zhu/Tcf3^tm3Zhu

Tcf3^tm4.1Cmu/Tcf3^tm4.1Cmu

Tcf3^{tm6(Esr1*)Zhu}/Tcf3^{tm6(Esr1*)Zhu}

Tcf3^{tm1(TCF3/HLF)Homy}/Tcf3⁺

Tcf3^tm1.1Mbu/Tcf3⁺

Tcf3^tm1Cmu/Tcf3⁺

Tcf3^tm1Wein/Tcf3⁺

Tcf3^tm1Wein/Tcf3^tm3Zhu

Tcf3^tm1Zhu/Tcf3^tm2Zhu

Tcf3^tm1Mbu/Tcf3^tm1Mbu
Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ (conditional)

Cd19^tm1(cre)Cgn/Cd19⁺
Tcf3^tm1Mbu/Tcf3^tm1.2Mbu (conditional)

Tcf3^{tm1(TCF3/HLF)Homy}/Tcf3⁺
Tg(Mx1-cre)1Cgn/0 (conditional)

Tcf3^tm1Mbu/Tcf3^tm1.2Mbu
Tg(Fcer2a-cre)5Mbu/0 (conditional)

Tcf3^tm1Mbu/Tcf3^tm1.2Mbu
Tg(Aicda-cre)9Mbu/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 05/14/2024 MGI 6.23