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Symbol
Name
ID

Spp1
secreted phosphoprotein 1
MGI:98389

Phenotype annotations related to hematopoietic system

Darker colors indicate more annotations

Human Phenotypes	Increased circulating IgA level	Increased circulating IgG level	Decreased circulating antibody level	Paraproteinemia	Anemia	Prolonged prothrombin time	Multiple myeloma	Elevated erythrocyte sedimentation rate	Splenomegaly	Hepatosplenomegaly
Disease(s) Associated with SPP1	Increased circulating IgA level	Increased circulating IgG level	Decreased circulating antibody level	Paraproteinemia	Anemia	Prolonged prothrombin time	Multiple myeloma	Elevated erythrocyte sedimentation rate	Splenomegaly	Hepatosplenomegaly
biliary atresia
multiple myeloma
pancreatic cancer
rheumatoid arthritis

Mouse Phenotypes

abnormal macrophage chemotaxis

impaired macrophage chemotaxis

abnormal leukocyte migration

abnormal blood cell morphology/development

increased bone marrow cell number

decreased hematocrit

decreased hemoglobin content

decreased dendritic cell number

increased lymphocyte cell number

decreased macrophage cell number

decreased osteoclast cell number

increased macrophage cell number

increased osteoclast cell number

decreased leukocyte cell number

increased hematopoietic stem cell number

abnormal macrophage morphology

abnormal microglial cell morphology

abnormal hematopoietic system physiology

abnormal leukocyte physiology

abnormal macrophage physiology

abnormal osteoclast physiology

Availability

Mouse Genotype

Spp1^tm1.1Dhd/Spp1^tm1.1Dhd

Spp1^tm1Blh/Spp1^tm1Blh

Spp1^tm1Rit/Spp1^tm1Rit

Spp1^Ric-r/Spp1⁺

Spp1^tm1Blh/Spp1⁺

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 05/14/2024 MGI 6.23