Symbol
Name
ID

Pbx1
pre B cell leukemia homeobox 1
MGI:97495

Phenotype annotations related to hematopoietic system

Darker colors indicate more annotations

Mouse Phenotypes

abnormal thymus morphology

small thymus

thymus hypoplasia

ectopic thymus

abnormal definitive hematopoiesis

decreased common myeloid progenitor cell number

absent common myeloid progenitor cells

decreased pro-B cell number

decreased double-negative T cell number

anemia

impaired hematopoiesis

decreased bone marrow cell number

abnormal common lymphocyte progenitor cell morphology

low mean erythrocyte cell number

decreased hematocrit

decreased mature B cell number

decreased B cell number

decreased pre-B cell number

decreased CD4-positive, alpha-beta T cell number

decreased CD8-positive, alpha-beta T cell number

decreased T cell number

decreased hematopoietic stem cell number

abnormal hematopoietic stem cell morphology

abnormal spleen morphology

abnormal spleen mesenchyme morphology

small spleen

spleen hypoplasia

absent spleen

Availability

Mouse Genotype

Pbx1^em1Dunw/Pbx1^em1Dunw

Pbx1^tm1Mlc/Pbx1^tm1Mlc

Pbx1^tm1Mlc/Pbx1^tm2.1Mlc

Nkx2-5^tm2(cre)Rph/Nkx2-5⁺
Pbx1^tm1.1Koss/Pbx1^tm1.1Koss (conditional)

Pbx1^tm1.1Koss/Pbx1^tm1.1Koss
Tg(WT1-cre)AG11Dbdr/0 (conditional)

Pbx1^tm1Koss/Pbx1^tm1Koss
Nkx2-5^tm2(cre)Rph/Nkx2-5⁺ (conditional)

Pbx1^tm1.1Koss/Pbx1^tm1.2Koss
Tmem163^{Tg(ACTB-cre)2Mrt}/0 (conditional)

Pbx1^tm1Mlc/Pbx1^tm3.1Mlc
Tg(Tek-cre)1Ywa/0 (conditional)

Pbx1^tm1Mlc/Pbx1^tm3.1Mlc
Tg(Mx1-cre)1Cgn/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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