Symbol
Name
ID

Nfkb1
nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105
MGI:97312

Phenotype annotations related to hematopoietic system

Darker colors indicate more annotations

Human Phenotypes	Decreased circulating antibody level	Autoimmune hemolytic anemia	Thrombocytopenia
Disease(s) Associated with NFKB1
common variable immunodeficiency 12

Mouse Phenotypes

decreased B cell proliferation

increased B cell proliferation

decreased T cell proliferation

enlarged spleen

abnormal class switch recombination

myeloid hyperplasia

extramedullary hematopoiesis

abnormal bone marrow cell morphology/development

decreased erythrocyte cell number

decreased mean corpuscular hemoglobin concentration

decreased myeloid dendritic cell number

decreased B-1 B cell number

decreased B-1a cell number

decreased marginal zone B cell number

decreased NK cell number

decreased central memory CD4-positive, alpha-beta T cell number

decreased effector memory CD4-positive, alpha-beta T cell number

increased central memory CD8 positive, alpha-beta T cell number

decreased CD8-positive, naive alpha-beta T cell number

decreased NK T cell number

decreased memory T cell number

decreased regulatory T cell number

decreased single-positive T cell number

decreased osteoclast cell number

increased leukocyte cell number

abnormal lymphocyte physiology

abnormal B cell physiology

decreased IgA level

decreased IgE level

increased IgE level

decreased IgG1 level

increased IgG1 level

decreased IgG3 level

decreased IgG level

decreased IgM level

decreased immunoglobulin level

increased immunoglobulin level

abnormal CD4-positive, alpha-beta T cell physiology

abnormal macrophage physiology

Availability

Mouse Genotype

Nfkb1^M1Btlr/Nfkb1^M1Btlr

Nfkb1^m2Btlr/Nfkb1^m2Btlr

Nfkb1^M3Btlr/Nfkb1^M3Btlr

Nfkb1^M4Btlr/Nfkb1^M4Btlr

Nfkb1^M5Btlr/Nfkb1^M5Btlr

Nfkb1^M6Btlr/Nfkb1^M6Btlr

Nfkb1^{tm1a(KOMP)Wtsi}/Nfkb1^{tm1a(KOMP)Wtsi}

Nfkb1^tm1Bal/Nfkb1^tm1Bal

Nfkb1^tm1Brv/Nfkb1^tm1Brv

Nfkb1^tm1Sley/Nfkb1^tm1Sley

Nfkb1^M1Btlr/Nfkb1⁺

Nfkb1^m2Btlr/Nfkb1⁺

Nfkb1^M3Btlr/Nfkb1⁺

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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