Symbol
Name
ID

Myb
myeloblastosis oncogene
MGI:97249

Phenotype annotations related to hematopoietic system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Mouse Phenotypes

hematopoietic system phenotype

abnormal megakaryocyte differentiation

decreased T cell proliferation

abnormal embryonic erythropoiesis

small thymus

thymus hypoplasia

decreased thymocyte number

enlarged spleen

abnormal definitive hematopoiesis

decreased common myeloid progenitor cell number

absent common myeloid progenitor cells

abnormal erythropoiesis

abnormal B cell differentiation

arrested B cell differentiation

abnormal T cell differentiation

abnormal double-negative T cell morphology

decreased double-negative T cell number

increased double-negative T cell number

decreased double-positive T cell number

arrested T cell differentiation

anemia

increased bone marrow cell number

abnormal megakaryocyte morphology

increased megakaryocyte cell number

abnormal common lymphocyte progenitor cell morphology

decreased erythroid progenitor cell number

abnormal myeloblast morphology/development

decreased eosinophil cell number

abnormal erythrocyte morphology

decreased erythrocyte cell number

decreased hematocrit

increased nucleated erythrocyte cell number

increased number of Howell-Jolly bodies

macrocytosis

polychromatophilia

decreased neutrophil cell number

thrombocytosis

abnormal platelet shape

decreased mature B cell number

decreased B-1 B cell number

decreased B cell number

decreased pre-B cell number

decreased CD4-positive, alpha-beta T cell number

decreased CD8-positive, alpha-beta T cell number

increased CD8-positive, alpha-beta T cell number

decreased gamma-delta T cell number

decreased T cell number

decreased single-positive T cell number

reticulocytosis

decreased hematopoietic stem cell number

increased hematopoietic stem cell number

abnormal hematopoietic stem cell morphology

abnormal leukocyte morphology

abnormal single-positive T cell number

abnormal spleen morphology

increased spleen red pulp amount

small spleen

decreased spleen white pulp amount

Availability

Mouse Genotype

Myb^boo/Myb^boo

Myb^M303V/Myb^M303V

Myb^tm1.1Cgn/Myb^tm1.1Cgn

Myb^tm1Jof/Myb^tm1Jof

Myb^tm1Ssp/Myb^tm1Ssp

Myb^tm2.2Epr/Myb^tm2.2Epr

Tg(CD2-Myb/en)2Kmw/Tg(CD2-Myb/en)2Kmw

Myb^tm1.1Cgn/Myb⁺

Myb^tm1Jof/Myb^tm1Ssp

Tg(CD2-Myb/en)2Kmw/?

Myb^tm1Cgn/Myb^tm1Cgn
Tg(Lck-cre)548Jxm/0 (conditional)

Myb^tm1Cgn/Myb^tm1Cgn
Tg(Lck-cre)1Cwi/0 (conditional)

Myb^tm1Epr/Myb^tm1Epr
Tg(Lck-cre)548Jxm/0 (conditional)

Myb^tm1Epr/Myb^tm1Epr
Tg(Cd4-cre)1Cwi/0 (conditional)

Myb^tm1Cgn/Myb^tm1.1Cgn
Tg(Lck-cre)548Jxm/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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