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Symbol
Name
ID 		Kmt2a
lysine (K)-specific methyltransferase 2A
MGI:96995
Phenotype annotations related to hematopoietic system
Darker colors indicate more annotations
Human Phenotypes
Purpura
Myelofibrosis
Hemophagocytosis
Acute myeloid leukemia
Myeloproliferative disorder
Extramedullary hematopoiesis
Lymphoma
Splenomegaly
Disease(s) Associated with KMT2A
acute myeloid leukemia
myelofibrosis
non-Hodgkin lymphoma

Mouse Phenotypes
abnormal hematopoietic system morphology/development
abnormal blood cell morphology/development
abnormal definitive hematopoiesis
abnormal common myeloid progenitor cell morphology
decreased common myeloid progenitor cell number
abnormal myelopoiesis
anemia
decreased bone marrow cell number
abnormal common lymphocyte progenitor cell morphology
decreased erythroid progenitor cell number
increased erythroid progenitor cell number
abnormal proerythroblast morphology
decreased erythrocyte cell number
decreased hemoglobin content
thrombocytopenia
decreased B cell number
decreased pre-B cell number
decreased hematopoietic stem cell number
abnormal hematopoietic stem cell morphology
abnormal bone marrow cell physiology
abnormal hematopoietic stem cell physiology
Availability Mouse Genotype
Kmt2atm1.1Brad/Kmt2atm1.1Brad
Kmt2atm1.1Mlc/Kmt2atm1.1Mlc
Kmt2atm2.1Mlc/Kmt2atm2.1Mlc
Kmt2atm1Clgr/Kmt2a+
Kmt2atm1Sjk/Kmt2a+
Kmt2atm1.1Erns/Kmt2atm1.1Erns
Tg(Mx1-cre)1Cgn/0  (conditional)
Kmt2atm1.1Erns/Kmt2atm1.1Erns  (conditional)
Kmt2atm1Brad/Kmt2atm1Brad
Commd10Tg(Vav1-icre)A2Kio/?  (conditional)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/28/2024
MGI 6.13 		The Jackson Laboratory