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Symbol
Name
ID
Lyn
LYN proto-oncogene, Src family tyrosine kinase
MGI:96892
Phenotype annotations related to hematopoietic system
Darker colors indicate more annotations

Mouse Phenotypes
decreased B cell proliferation
increased B cell proliferation
small thymus
enlarged spleen
increased spleen weight
spleen hyperplasia
abnormal class switch recombination
decreased transitional stage B cell number
increased immature B cell number
abnormal myelopoiesis
myeloid hyperplasia
extramedullary hematopoiesis
anemia
impaired hematopoiesis
increased erythroid progenitor cell number
increased basophil cell number
increased eosinophil cell number
abnormal proerythroblast morphology
decreased erythrocyte cell number
decreased hematocrit
decreased hemoglobin content
increased red blood cell distribution width
increased mast cell number
increased neutrophil cell number
increased granulocyte number
thrombocytopenia
increased mean platelet volume
increased dendritic cell number
decreased mature B cell number
decreased B-1 B cell number
decreased follicular B cell number
decreased marginal zone B cell number
increased B-1 B cell number
increased plasma cell number
decreased B cell number
decreased T cell number
increased T cell number
increased activated T cell number
decreased lymphocyte cell number
increased macrophage cell number
increased monocyte cell number
decreased leukocyte cell number
increased leukocyte cell number
abnormal B cell morphology
abnormal spleen morphology
decreased spleen red pulp amount
decreased spleen weight
spleen hypoplasia
disorganized spleen B cell follicle
decreased spleen white pulp amount
increased spleen white pulp amount
abnormal leukocyte physiology
abnormal B cell physiology
abnormal B cell activation
increased IgA level
increased IgE level
increased IgG1 level
increased IgG2b level
decreased IgG level
increased IgG level
decreased IgM level
increased IgM level
increased immunoglobulin level
abnormal T cell activation
abnormal macrophage physiology
abnormal microglial cell physiology
Availability Mouse Genotype
Lynm1Anu/Lynm1Anu
LynM1Btlr/LynM1Btlr
Lynm2Anu/Lynm2Anu
LynM2Btlr/LynM2Btlr
LynM3Btlr/LynM3Btlr
Lynm4Btlr/Lynm4Btlr
Lynmld4/Lynmld4
Lyntm1Ard/Lyntm1Ard
Lyntm1b(EUCOMM)Hmgu/Lyntm1b(EUCOMM)Hmgu
Lyntm1Mhi/Lyntm1Mhi
Lyntm1Sor/Lyntm1Sor
Lyntm1Tya/Lyntm1Tya
Lynweeb/Lynweeb
LynM1Btlr/Lyn+
LynM2Btlr/Lyn+
LynM3Btlr/Lyn+
Lyntm1.1Calo/Lyntm1.1Calo
Tg(Itgax-cre)1-1Reiz/0  (conditional)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/28/2024
MGI 6.13
The Jackson Laboratory