Symbol
Name
ID

Kit
KIT proto-oncogene receptor tyrosine kinase
MGI:96677

Phenotype annotations related to hematopoietic system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Cutaneous mastocytosis	Acute myeloid leukemia
Disease(s) Associated with KIT	Cutaneous mastocytosis	Acute myeloid leukemia
acute myeloid leukemia
mastocytosis

Mouse Phenotypes

hematopoietic system phenotype

increased mast cell degranulation

decreased thymocyte number

enlarged spleen

spleen hyperplasia

abnormal erythropoiesis

abnormal stress erythropoiesis

abnormal B cell differentiation

arrested B cell differentiation

abnormal T cell differentiation

anemia

macrocytic anemia

microcytic anemia

decreased bone marrow cell number

increased megakaryocyte cell number

abnormal erythroid progenitor cell morphology

increased erythroid progenitor cell number

decreased basophil cell number

abnormal proerythroblast morphology

increased erythroblast number

abnormal erythrocyte morphology

decreased erythrocyte cell number

low mean erythrocyte cell number

increased erythrocyte cell number

high mean erythrocyte cell number

polycythemia

decreased hematocrit

increased hematocrit

decreased hemoglobin content

increased hemoglobin content

decreased mean corpuscular hemoglobin

increased mean corpuscular hemoglobin

increased mean corpuscular hemoglobin concentration

decreased mean corpuscular volume

increased mean corpuscular volume

increased nucleated erythrocyte cell number

increased erythrocyte protoporphyrin level

macrocytosis

decreased mast cell number

increased mast cell number

abnormal mast cell morphology

thrombocytosis

increased mean platelet volume

decreased B cell number

increased B cell number

spleen hypoplasia

abnormal erythrocyte physiology

abnormal mast cell physiology

impaired neutrophil recruitment

abnormal bone marrow cell physiology

Availability

Mouse Genotype

Kit^Mhdasco1/Kit^Mhdasco1

Kit^Mhdasco5/Kit^Mhdasco5

Kit^Ssm/Kit^Ssm

Kit^tm1.1Bsm/Kit^tm1.1Bsm

Kit^tm1Alf/Kit^tm1Alf

Kit^tm1Ber/Kit^tm1Ber

Kit^tm1Bpr/Kit^tm1Bpr

Kit^tm1Bsm/Kit^tm1Bsm

Kit^tm1Hntr/Kit^tm1Hntr

Kit^tm2Ber/Kit^tm2Ber

Kit^tm3.1Bsm/Kit^tm3.1Bsm

Kit^tm3Ber/Kit^tm3Ber

Kit^W-3Bao/Kit^W-3Bao

Kit^W-25J/Kit^W-25J

Kit^W-27H/Kit^W-27H

Kit^W-28H/Kit^W-28H

Kit^W-36H/Kit^W-36H

Kit^W-41J/Kit^W-41J

Kit^W-42J/Kit^W-42J

Kit^W-44J/Kit^W-44J

Kit^W-55J/Kit^W-55J

Kit^W-73J/Kit^W-73J

Kit^W-a/Kit^W-a

Kit^W-b/Kit^W-b

Kit^W-Btlr/Kit^W-Btlr

Kit^W-ct/Kit^W-ct

Kit^W-e/Kit^W-e

Kit^W-f/Kit^W-f

Kit^W-j/Kit^W-j

Kit^W-n/Kit^W-n

Kit^W-pw/Kit^W-pw

Kit^W-rio/Kit^W-rio

Kit^W-s/Kit^W-s

Kit^W-v/Kit^W-v

Kit^W-vkd/Kit^W-vkd

Kit^W/Kit^W

Kit^Wads/Kit^Wads

Kit^Whc1/Kit^Whc1

Kit^M1Hmgu/Kit⁺

Kit^tm2Ber/Kit^tm3.1Bsm

Kit^tm2Bsm/Kit⁺

Kit^tm4.1Bsm/Kit⁺

Kit^tm5.1Bsm/Kit⁺

Kit^W-3Bao/Kit⁺

Kit^W-34J/Kit⁺

Kit^W-35J/Kit⁺

Kit^W-37J/Kit⁺

Kit^W-37J/Kit^W

Kit^W-38J/Kit⁺

Kit^W-39J/Kit⁺

Kit^W-40J/Kit⁺

Kit^W-41J/Kit⁺

Kit^W-42J/Kit⁺

Kit^W-42J/Kit^W

Kit^W-43J/Kit⁺

Kit^W-44J/Kit⁺

Kit^W-55J/Kit⁺

Kit^W-b/Kit^W-s

Kit^W-Bs/Kit^W-v

Kit^W-ct/Kit⁺

Kit^W-f/Kit⁺

Kit^W-Jic/Kit⁺

Kit^W-Jic/Kit^W

Kit^W-n/Kit^W

Kit^W-v/Kit⁺

Kit^W/Kit⁺

Kit^W/Kit^W-v

Kit^Wads/Kit⁺

Tg(Cma1-cre)ARoer/0
Tg(Kit*D814V)1Roer/0 (conditional)

Tg(Cma1-cre)ARoer/0
Tg(Kit*D814V)3Roer/0 (conditional)

Tg(CMV-cre)1Cgn/0
Tg(Kit*D814V)1Roer/0 (conditional)

Tg(CMV-cre)1Cgn/0
Tg(Kit*D814V)3Roer/0 (conditional)

Tg(Kit*D814V)1Roer/0
Tg(Mx1-cre)1Cgn/0 (conditional)

Tg(Kit*D814V)2Roer/0
Tg(Mx1-cre)1Cgn/0 (conditional)

Tg(Kit*D814V)3Roer/0
Tg(Mx1-cre)1Cgn/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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