Symbol
Name
ID

Il2rb
interleukin 2 receptor, beta chain
MGI:96550

Phenotype annotations related to hematopoietic system

Darker colors indicate more annotations

Human Phenotypes	Increased circulating IgG level	Autoimmune hemolytic anemia	Decreased CD4:CD8 ratio	Splenomegaly
Disease(s) Associated with IL2RB
immunodeficiency 63

Mouse Phenotypes

decreased T cell proliferation

thymus hypoplasia

enlarged spleen

abnormal common myeloid progenitor cell morphology

abnormal CD8-positive, alpha-beta T cell differentiation

abnormal T cell clonal deletion

decreased double-positive T cell number

increased susceptibility to autoimmune hemolytic anemia

increased erythroid progenitor cell number

increased neutrophil cell number

increased granulocyte number

increased plasma cell number

decreased B cell number

decreased NK cell number

increased effector memory CD4-positive, alpha-beta T cell number

decreased CD4-positive, alpha-beta T cell number

increased CD4-positive, alpha-beta T cell number

decreased central memory CD8 positive, alpha-beta T cell number

increased effector memory CD8-positive, alpha-beta T cell number

decreased CD8-positive, naive alpha-beta T cell number

decreased CD8-positive, alpha-beta T cell number

increased CD8-positive, alpha-beta T cell number

decreased NK T cell number

decreased memory T cell number

decreased regulatory T cell number

increased activated T cell number

abnormal mononuclear cell morphology

abnormal lymphocyte morphology

abnormal marginal zone B cell morphology

abnormal T cell morphology

abnormal spleen periarteriolar lymphoid sheath morphology

abnormal B cell activation

increased IgE level

increased IgG1 level

increased IgM level

abnormal T cell activation

Availability

Mouse Genotype

Il2rb^m1Btlr/Il2rb^m1Btlr

Il2rb^m2Btlr/Il2rb^m2Btlr

Il2rb^M3Btlr/Il2rb^M3Btlr

Il2rb^tm1Mak/Il2rb^tm1Mak

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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