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Symbol
Name
ID 		Il10
interleukin 10
MGI:96537
Phenotype annotations related to hematopoietic system
Darker colors indicate more annotations
Human Phenotypes
Increased circulating IgA level
Increased circulating IgE level
Increased circulating IgG level
Monoclonal immunoglobulin M proteinemia
Polyclonal elevation of IgM
Decreased circulating antibody level
Paraproteinemia
Abnormality of blood and blood-forming tissues
Abnormal bleeding
Bleeding with minor or no trauma
Epistaxis
Gingival bleeding
Gastrointestinal hemorrhage
Hematemesis
Melena
Retinal hemorrhage
Intracranial hemorrhage
Intraventricular hemorrhage
Joint hemorrhage
Muscle hemorrhage
Diffuse alveolar hemorrhage
Localized pulmonary hemorrhage
Oral cavity bleeding
Persistent bleeding after trauma
Bruising susceptibility
Purpura
Petechiae
Spontaneous hematomas
Abnormal megakaryocyte morphology
Increased megakaryocyte colony forming unit count
Anemia
Hemolytic anemia
Anemia of inadequate production
Normocytic anemia
Poikilocytosis
Acanthocytosis
Leukocytosis
Leukopenia
Impaired lymphocyte transformation with phytohemagglutinin
Abnormal granulocyte morphology
Abnormal basophil morphology
Abnormality of neutrophils
Granulomatosis
Hemophagocytosis
Leukemia
Ph-positive acute lymphoblastic leukemia
Chronic myelogenous leukemia
Myeloproliferative disorder
Thromboembolism
Superficial thrombophlebitis
Reduced factor VIII activity
Hypercoagulability
Prolonged partial thromboplastin time
Thrombocytopenia
Congenital thrombocytopenia
Intermittent thrombocytopenia
Thrombocytosis
Abnormal platelet shape
Abnormal platelet volume
Decreased mean platelet volume
Lymphoma
Multiple myeloma
Elevated erythrocyte sedimentation rate
Splenic rupture
Splenomegaly
Hepatosplenomegaly
Disease(s) Associated with IL10
autoimmune thrombocytopenic purpura
Behcet's disease
chronic myeloid leukemia
factor VIII deficiency
graft-versus-host disease
granulomatosis with polyangiitis
lymphoplasmacytic lymphoma
multiple myeloma
pancreatic cancer
rheumatoid arthritis
systemic lupus erythematosus
thrombocytopenia

Mouse Phenotypes
decreased T cell proliferation
increased thymus weight
thymus hyperplasia
spleen hyperplasia
abnormal myelopoiesis
anemia
hypochromic anemia
microcytic anemia
absent erythroid progenitor cell
decreased erythrocyte cell number
decreased hemoglobin content
increased granulocyte number
increased myeloid dendritic cell number
abnormal lymphocyte cell number
increased plasma cell number
increased B cell number
increased CD4-positive, alpha-beta T cell number
increased T cell number
abnormal leukocyte morphology
abnormal myeloid leukocyte morphology
decreased spleen iron level
decreased spleen red pulp amount
increased IgE level
increased IgG1 level
increased IgG2a level
abnormal CD8-positive, alpha-beta T cell physiology
abnormal regulatory T cell physiology
Availability Mouse Genotype
Il10tm1.1Roer/Il10tm1.1Roer
Il10tm1Cgn/Il10tm1Cgn
Il10tm1Roer/Il10tm1Roer
Foxp3tm4(YFP/icre)Ayr/Y  (conditional)
Cd19tm1(cre)Cgn/Cd19+
Il10tm1Roer/Il10tm1Roer  (conditional)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/14/2024
MGI 6.23 		The Jackson Laboratory