|
Symbol Name ID |
Idh1
isocitrate dehydrogenase 1 (NADP+), soluble MGI:96413 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Acute myeloid leukemia |
Myelodysplasia |
| Disease(s) Associated with IDH1 | ||
| acute myeloid leukemia | ||
| myelodysplastic syndrome |
| Mouse Phenotypes | hematopoietic system phenotype |
enlarged spleen |
abnormal common myeloid progenitor cell morphology |
decreased common myeloid progenitor cell number |
extramedullary hematopoiesis |
anemia |
abnormal bone marrow cell morphology/development |
decreased bone marrow cell number |
abnormal common lymphocyte progenitor cell morphology |
abnormal myeloblast morphology/development |
decreased hematocrit |
decreased hemoglobin content |
decreased B cell number |
decreased CD4-positive, alpha-beta T cell number |
increased CD4-positive, alpha-beta T cell number |
decreased CD8-positive, alpha-beta T cell number |
increased hematopoietic stem cell number |
abnormal spleen morphology |
abnormal bone marrow cell physiology |
|
| Availability | Mouse Genotype | |||||||||||||||||||
| Idh1tm1Mak/Idh1tm1Mak Commd10Tg(Vav1-icre)A2Kio/Commd10+ (conditional) |
* | |||||||||||||||||||
| Idh1tm1Mak/Idh1tm1Mak Lyz2tm1(cre)Ifo/Lyz2+ (conditional) |
* | |||||||||||||||||||
| Idh1tm2Mak/Idh1tm2Mak Lyz2tm1(cre)Ifo/Lyz2+ (conditional) |
* | |||||||||||||||||||
| Idh1tm2Mak/Idh1tm2Mak Commd10Tg(Vav1-icre)A2Kio/Commd10+ (conditional) |
* | |||||||||||||||||||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/14/2024 MGI 6.23 |
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