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Symbol
Name
ID 		Cd40
CD40 antigen
MGI:88336
Phenotype annotations related to hematopoietic system
*Aspects of the system are reported to show a normal phenotype.
Darker colors indicate more annotations
Human Phenotypes
Decreased circulating IgA concentration
Increased circulating IgA concentration
Decreased circulating IgE concentration
Decreased circulating IgG concentration
Increased circulating IgG concentration
Increased circulating IgM level
Decreased circulating immunoglobulin concentration
Paraproteinemia
Impaired Ig class switch recombination
Impaired memory B cell generation
Gastrointestinal hemorrhage
Abnormal bone marrow cell morphology
Anemia
Hemolytic anemia
Decreased total neutrophil count
Decreased total leukocyte count
Decreased CD4+ T cell proportion
Thrombocytopenia
Lymphoma
Burkitt lymphoma
Multiple myeloma
Elevated erythrocyte sedimentation rate
Abnormality of the spleen
Splenomegaly
Disease(s) Associated with CD40
Burkitt lymphoma
immunodeficiency with hyper IgM type 3
multiple myeloma
non-Hodgkin lymphoma
rheumatoid arthritis
systemic lupus erythematosus

Mouse Phenotypes
hematopoietic system phenotype
decreased neutrophil cell number
absent germinal center B cells
decreased B cell number
absent spleen germinal center
decreased spleen germinal center number
decreased spleen germinal center size
abnormal immunoglobulin level
decreased IgA level
decreased IgE level
decreased IgG1 level
decreased IgG2a level
decreased IgG2b level
decreased IgG3 level
increased IgG3 level
decreased IgG level
decreased IgM level
increased IgM level
decreased immunoglobulin level
decreased platelet aggregation
Availability Mouse Genotype
Cd40m2Btlr/Cd40m2Btlr
Cd40tm1Arah/Cd40tm1Arah
Cd40tm1Geha/Cd40tm1Geha
Cd40tm1Kik/Cd40tm1Kik *
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
03/31/2026
MGI 6.24 		The Jackson Laboratory