Symbol
Name
ID

Cd28
CD28 antigen
MGI:88327

Phenotype annotations related to hematopoietic system

Darker colors indicate more annotations

Mouse Phenotypes

increased T cell apoptosis

decreased T cell proliferation

increased T cell proliferation

increased splenocyte proliferation

enlarged thymus

enlarged spleen

abnormal lymphopoiesis

abnormal class switch recombination

increased B cell number

decreased CD4-positive, alpha-beta T cell number

increased CD4-positive, alpha-beta T cell number

decreased regulatory T cell number

decreased T cell number

increased activated T cell number

increased leukocyte cell number

decreased spleen germinal center number

abnormal germinal center B cell physiology

abnormal immunoglobulin level

decreased IgG1 level

decreased IgG2a level

increased IgG2a level

decreased IgG2b level

decreased IgM level

decreased immunoglobulin level

abnormal NK cell physiology

abnormal CD4-positive, alpha-beta T cell physiology

abnormal T-helper 1 physiology

abnormal T-helper 2 physiology

abnormal cytotoxic T cell physiology

abnormal regulatory T cell physiology

Availability

Mouse Genotype

Cd28^{tm1a(EUCOMM)Hmgu}/Cd28^{tm1a(EUCOMM)Hmgu}

Cd28^tm1Jmg/Cd28^tm1Jmg

Cd28^tm1Mak/Cd28^tm1Mak

Cd28^tm1Pjl/Cd28^tm1Pjl

Cd28^tm1Shr/Cd28^tm1Shr

Cd28^tm1Jmg/Cd28^tm1Mak

Cd28^tm1.1Huen/Cd28^tm1.1Huen
Gt(ROSA)26Sor^{tm9(cre/ESR1)Arte}/Gt(ROSA)26Sor⁺ (conditional)

Cd28^tm1Ltu/Cd28^tm1Ltu
Foxp3^{tm4(YFP/icre)Ayr}/Foxp3⁺ (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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