Symbol
Name
ID

Asxl1
ASXL transcriptional regulator 1
MGI:2684063

Phenotype annotations related to hematopoietic system

Darker colors indicate more annotations

Human Phenotypes	Purpura	Myelofibrosis	Hemophagocytosis	Acute myeloid leukemia	Myeloproliferative disorder	Extramedullary hematopoiesis	Myelodysplasia	Splenomegaly
Disease(s) Associated with ASXL1	Purpura	Myelofibrosis	Hemophagocytosis	Acute myeloid leukemia	Myeloproliferative disorder	Extramedullary hematopoiesis	Myelodysplasia	Splenomegaly
acute myeloid leukemia
myelodysplastic syndrome
myelofibrosis

Mouse Phenotypes

abnormal thymus morphology

hepatosplenomegaly

enlarged spleen

spleen hyperplasia

abnormal blood cell morphology/development

abnormal definitive hematopoiesis

abnormal common myeloid progenitor cell morphology

abnormal lymphopoiesis

increased double-negative T cell number

abnormal myelopoiesis

myeloid hyperplasia

extramedullary hematopoiesis

anemia

impaired hematopoiesis

abnormal bone marrow cell morphology/development

decreased bone marrow cell number

increased bone marrow cell number

increased granulocyte monocyte progenitor cell number

abnormal megakaryocyte morphology

increased megakaryocyte cell number

decreased erythroid progenitor cell number

increased erythroid progenitor cell number

decreased erythrocyte cell number

decreased hemoglobin content

decreased mean corpuscular hemoglobin

increased mean corpuscular hemoglobin concentration

increased nucleated erythrocyte cell number

increased number of Howell-Jolly bodies

polychromatophilia

decreased neutrophil cell number

increased neutrophil cell number

abnormal neutrophil morphology

thrombocytopenia

thrombocytosis

decreased mature B cell number

decreased B cell number

decreased pre-B cell number

decreased CD4-positive, alpha-beta T cell number

decreased T cell number

increased single-positive T cell number

decreased lymphocyte cell number

decreased monocyte cell number

increased monocyte cell number

decreased leukocyte cell number

increased leukocyte cell number

increased myeloid cell number

decreased hematopoietic stem cell number

increased hematopoietic stem cell number

abnormal hematopoietic stem cell morphology

decreased megakaryocyte-erythroid progenitor cell number

abnormal leukocyte morphology

abnormal myeloid cell morphology

abnormal spleen morphology

decreased spleen red pulp amount

decreased spleen weight

small spleen

spleen atrophy

abnormal spleen white pulp morphology

decreased splenocyte number

abnormal neutrophil physiology

abnormal hematopoietic stem cell physiology

Availability

Mouse Genotype

Asxl1^tm1.1Mjxu/Asxl1^tm1.1Mjxu

Asxl1^tm1Bc/Asxl1^tm1Bc

Asxl1^tm1.1Mjxu/Asxl1⁺

Asxl1^{tm1a(EUCOMM)Wtsi}/Asxl1⁺

Tg(Vav1-Asxl1*Y588X)#Fcy/0

Asxl1^tm1.1Iaai/Asxl1^tm1.1Iaai
Tg(Mx1-cre)1Cgn/0 (conditional)

Asxl1^tm1.1Iaai/Asxl1^tm1.1Iaai
Tg(VAV1-cre)1Graf/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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