Symbol
Name
ID

Nlrp3
NLR family, pyrin domain containing 3
MGI:2653833

Phenotype annotations related to hematopoietic system

Darker colors indicate more annotations

Human Phenotypes	Purpura	Anemia	Eosinophilia	Leukocytosis	Abnormal granulocyte morphology	Abnormality of neutrophils	Abnormality of thrombocytes	Elevated erythrocyte sedimentation rate	Splenomegaly	Hepatosplenomegaly
Disease(s) Associated with NLRP3	Purpura	Anemia	Eosinophilia	Leukocytosis	Abnormal granulocyte morphology	Abnormality of neutrophils	Abnormality of thrombocytes	Elevated erythrocyte sedimentation rate	Splenomegaly	Hepatosplenomegaly
CINCA Syndrome
familial cold autoinflammatory syndrome 1
Muckle-Wells syndrome

Mouse Phenotypes

abnormal osteoclast differentiation

enlarged spleen

anemia

decreased erythrocyte cell number

increased neutrophil cell number

increased granulocyte number

thrombocytosis

abnormal CD4-positive, alpha-beta T cell number

increased T-helper 1 cell number

increased activated T cell number

decreased lymphocyte cell number

increased lymphocyte cell number

increased osteoclast cell number

increased monocyte cell number

increased leukocyte cell number

abnormal spleen red pulp morphology

abnormal macrophage physiology

abnormal macrophage cytokine production

abnormal bone marrow cell physiology

Availability

Mouse Genotype

Nlrp3^M7Btlr/Nlrp3^M7Btlr

Nlrp3^tm1Flv/Nlrp3^tm1Flv

Nlrp3^M7Btlr/Nlrp3⁺

Nlrp3^tm1Wstr/Nlrp3⁺

Nlrp3^tm3.1Hhf/Nlrp3⁺

Nlrp3^tm1Hhf/Nlrp3⁺
Lyz2^tm1(cre)Ifo/Lyz2⁺ (conditional)

Nlrp3^tm1Hhf/Nlrp3⁺
Tg(Zp3-cre)3Mrt/? (conditional)

Nlrp3^tm1Hhf/Nlrp3⁺
Tg(CAG-cre/Esr1*)5Amc/? (conditional)

Nlrp3^tm2Hhf/Nlrp3⁺
Tg(CAG-cre/Esr1*)5Amc/? (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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