Symbol
Name
ID

Foxp3
forkhead box P3
MGI:1891436

Phenotype annotations related to hematopoietic system

Darker colors indicate more annotations

Human Phenotypes

Increased circulating IgE level

Anemia

Autoimmune hemolytic anemia

Coombs-positive hemolytic anemia

Iron deficiency anemia

Eosinophilia

Neutropenia

Neutropenia in presence of anti-neutropil antibodies

Reduced proportion of CD4-negative, CD8-negative, alpha-beta regulatory T cells

Decreased FOXP3-expressing T cell count

Thrombocytopenia

Autoimmune thrombocytopenia

Splenomegaly

Disease(s) Associated with FOXP3

immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome

Mouse Phenotypes

increased T cell apoptosis

increased T cell proliferation

abnormal thymus morphology

abnormal thymus cortex morphology

small thymus

thymus hypoplasia

decreased thymocyte number

enlarged spleen

increased spleen weight

abnormal T cell differentiation

decreased double-positive T cell number

extramedullary hematopoiesis

anemia

decreased megakaryocyte cell number

abnormal megakaryocyte progenitor cell morphology

increased eosinophil cell number

abnormal erythrocyte morphology

decreased erythrocyte cell number

decreased hematocrit

decreased hemoglobin content

increased mean corpuscular volume

anisocytosis

poikilocytosis

polychromatophilia

thrombocytopenia

increased mean platelet volume

abnormal T cell subpopulation ratio

decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number

increased CD4-positive, alpha-beta T cell number

increased CD8-positive, alpha-beta T cell number

decreased regulatory T cell number

absent regulatory T cells

decreased T cell number

increased T cell number

increased activated T cell number

increased lymphocyte cell number

increased monocyte cell number

increased leukocyte cell number

abnormal lymphocyte morphology

abnormal CD4-positive, alpha beta T cell morphology

abnormal CD4-positive, CD25-positive, alpha-beta regulatory T cell morphology

abnormal effector T cell morphology

abnormal intraepithelial T cell morphology

abnormal regulatory T cell morphology

abnormal macrophage morphology

abnormal reticulocyte morphology

abnormal spleen morphology

increased spleen red pulp amount

intermingled spleen red and white pulp

abnormal spleen white pulp morphology

decreased spleen B cell follicle number

absent spleen marginal zone

increased spleen white pulp amount

abnormal lymphocyte physiology

abnormal B cell physiology

increased IgE level

increased IgG1 level

increased IgG level

increased IgM level

abnormal CD4-positive, alpha-beta T cell physiology

abnormal CD8-positive, alpha-beta T cell physiology

abnormal regulatory T cell physiology

Availability

Mouse Genotype

Foxp3^sf/Foxp3^sf
Tg(Rorc-EGFP)1Ebe/?

Foxp3^{tm1(CD2/CD52)Shori}/Foxp3^{tm1(CD2/CD52)Shori}

Foxp3^tm1.1Ayr/Foxp3^tm1.1Ayr

Foxp3^tm5.2Ayr/Foxp3^tm5.2Ayr

Foxp3^tm6.2Ayr/Foxp3^tm6.2Ayr

Foxp3^tm7.2Ayr/Foxp3^tm7.2Ayr

Foxp3^tm3Tch/Foxp3⁺

Foxp3^tm7.2Ayr/Foxp3⁺

Foxp3^sf/Y

Foxp3^tm1.1Ayr/Y

Foxp3^tm1Tch/Y

Foxp3^{tm2.1(EGFP/cre)Shori}/Y

Foxp3^tm2Flv/Y

Foxp3^tm3Tch/Y

Foxp3^tm1Ayr/Foxp3^tm1Ayr
Tg(Cd4-cre)1Cwi/? (conditional)

Foxp3^tm1Ayr/Y
Tg(Cd4-cre)1Cwi/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 05/14/2024 MGI 6.23