Symbol Name ID |
Icos
inducible T cell co-stimulator MGI:1858745 |
Darker colors indicate more annotations |
Human Phenotypes | Decreased circulating IgA level |
Decreased circulating IgG level |
Decreased circulating total IgM |
Secretory IgA deficiency |
Impaired T cell function |
Neutropenia in presence of anti-neutropil antibodies |
Decreased proportion of class-switched memory B cells |
B lymphocytopenia |
Abnormal T cell count |
Abnormal lymphocyte morphology |
Splenomegaly |
Disease(s) Associated with ICOS | |||||||||||
common variable immunodeficiency 1 | |||||||||||
immunoglobulin alpha deficiency |
Mouse Phenotypes | decreased T cell proliferation |
abnormal B cell selection |
abnormal class switch recombination |
abnormal T cell differentiation |
abnormal leukocyte cell number |
abnormal B cell number |
decreased germinal center B cell number |
decreased plasma cell number |
increased plasma cell number |
abnormal memory B cell number |
decreased CD4-positive, alpha-beta T cell number |
decreased T cell number |
abnormal spleen morphology |
abnormal spleen germinal center morphology |
decreased spleen germinal center number |
decreased spleen germinal center size |
abnormal B cell physiology |
abnormal immunoglobulin level |
decreased IgA level |
decreased IgE level |
decreased IgG1 level |
decreased IgG2a level |
decreased IgG2b level |
decreased IgG2c level |
increased IgG3 level |
decreased IgG level |
abnormal NK cell physiology |
abnormal T cell physiology |
abnormal CD4-positive, alpha-beta T cell physiology |
abnormal T-helper 2 physiology |
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Availability | Mouse Genotype | ||||||||||||||||||||||||||||||
Icostm1.1Wks/Icostm1.1Wks | |||||||||||||||||||||||||||||||
Icostm1Dgry/Icostm1Dgry | |||||||||||||||||||||||||||||||
Icostm1Flv/Icostm1Flv | |||||||||||||||||||||||||||||||
Icostm1Mak/Icostm1Mak | |||||||||||||||||||||||||||||||
Icostm1Shr/Icostm1Shr | |||||||||||||||||||||||||||||||
Icostm1Tkan/Icostm1Tkan |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/14/2024 MGI 6.23 |
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