Symbol
Name
ID

Nbn
nibrin
MGI:1351625

Phenotype annotations related to hematopoietic system

Darker colors indicate more annotations

Human Phenotypes

Dysgammaglobulinemia

Bone marrow hypocellularity

Aplastic anemia

Hemolytic anemia

Autoimmune hemolytic anemia

B lymphocytopenia

T lymphocytopenia

Acute leukemia

Acute lymphoblastic leukemia

T-cell acute lymphoblastic leukemias

Thrombocytopenia

Lymphoma

B-cell lymphoma

T-cell lymphoma

Disease(s) Associated with NBN

acute lymphoblastic leukemia

aplastic anemia

Nijmegen breakage syndrome

Mouse Phenotypes

decreased B cell proliferation

thymus hypoplasia

decreased thymocyte number

increased pro-B cell number

anemia

impaired hematopoiesis

decreased bone marrow cell number

decreased erythrocyte cell number

thrombocytosis

decreased mature B cell number

absent mature B cells

decreased B cell number

decreased pre-B cell number

decreased CD4-positive, alpha-beta T cell number

increased CD8-positive, alpha-beta T cell number

decreased T cell number

decreased leukocyte cell number

decreased myeloid cell number

abnormal T cell morphology

abnormal B cell physiology

decreased IgG1 level

decreased IgG2a level

decreased IgG2b level

decreased IgG3 level

decreased IgG level

Availability

Mouse Genotype

Nbn^tm1Xu/Nbn^tm1Xu

Nbn^tm2Zqw/Nbn^tm2Zqw
Tg(VAV1-cre)1Graf/0 (conditional)

Nbn^em7Jpt/Nbn^tm2Zqw
Tg(VAV1-cre)1Graf/0 (conditional)

Nbn^tm1Nus/Nbn^tm2Nus
Tg(CD19-cre/ERT2)1Cgn/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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