Symbol
Name
ID

Slc40a1
solute carrier family 40 (iron-regulated transporter), member 1
MGI:1315204

Phenotype annotations related to hematopoietic system

*	Aspects of the system are reported to show a normal phenotype.
!	Indicates phenotype varies with strain background.
	Darker colors indicate more annotations

Human Phenotypes	Anemia
Disease(s) Associated with SLC40A1	Anemia
hemochromatosis type 4

Mouse Phenotypes

hematopoietic system phenotype

increased splenocyte apoptosis

anemia

hypochromic microcytic anemia

abnormal erythrocyte morphology

increased erythrocyte cell number

polycythemia

decreased hematocrit

increased hematocrit

decreased hemoglobin content

increased hemoglobin content

decreased mean corpuscular hemoglobin

decreased mean corpuscular volume

increased mean corpuscular volume

anisocytosis

leptocytosis

poikilocytosis

reticulocytosis

abnormal spleen development

decreased spleen iron level

increased spleen iron level

small spleen

abnormal macrophage physiology

Availability

Mouse Genotype

Slc40a1^ffe/Slc40a1^ffe

Slc40a1^Pcm/Slc40a1^Pcm

Slc40a1^tm1.1Mmfe/Slc40a1^tm1.1Mmfe

Slc40a1^ffe/Slc40a1⁺

Slc40a1^Pcm/Slc40a1⁺

Slc40a1^tm1.1Mmfe/Slc40a1⁺

Slc40a1^tm1Nca/Slc40a1⁺

Meox2^tm1(cre)Sor/Meox2⁺
Slc40a1^tm2Nca/Slc40a1^tm2Nca (conditional)

Slc40a1^tm2Nca/Slc40a1^tm2Nca
Tg(Vil1-cre/ERT2)23Syr/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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