Symbol
Name
ID

Tnfrsf1a
tumor necrosis factor receptor superfamily, member 1a
MGI:1314884

Phenotype annotations related to hematopoietic system

Darker colors indicate more annotations

Human Phenotypes	Gastrointestinal hemorrhage	Bruising susceptibility	Purpura	Leukocytosis	Elevated erythrocyte sedimentation rate	Splenomegaly
Disease(s) Associated with TNFRSF1A	Gastrointestinal hemorrhage	Bruising susceptibility	Purpura	Leukocytosis	Elevated erythrocyte sedimentation rate	Splenomegaly
autosomal dominant familial periodic fever
IgA glomerulonephritis
rheumatoid arthritis

Mouse Phenotypes

increased basophil cell number

increased eosinophil cell number

decreased neutrophil cell number

increased neutrophil cell number

increased NK cell number

increased effector memory CD8-positive, alpha-beta T cell number

increased lymphocyte cell number

increased large unstained cell number

decreased monocyte cell number

increased leukocyte cell number

decreased microglial cell number

abnormal spleen germinal center morphology

decreased IgG1 level

decreased IgG level

abnormal macrophage physiology

Availability

Mouse Genotype

Tnfrsf1a^{em1(IMPC)Ccpcz}/Tnfrsf1a^{em1(IMPC)Ccpcz}

Tnfrsf1a^tm1Blt/Tnfrsf1a^tm1Blt

Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx

Tnfrsf1a^tm1Mak/Tnfrsf1a^tm1Mak

Tnfrsf1a^tm1Rsie/Tnfrsf1a^tm1Rsie

Tnfrsf1a^tm2.1Rsie/Tnfrsf1a^tm2.1Rsie

Tnfrsf1a^{tm2b(EUCOMM)Wtsi}/Tnfrsf1a^{tm2b(EUCOMM)Wtsi}

Tnfrsf1a^tm2.1Rsie/Tnfrsf1a⁺

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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