Symbol
Name
ID

Asah1
N-acylsphingosine amidohydrolase 1
MGI:1277124

Phenotype annotations related to hematopoietic system

Darker colors indicate more annotations

Human Phenotypes	Lipogranulomatosis	Splenomegaly
Disease(s) Associated with ASAH1	Lipogranulomatosis	Splenomegaly
Farber lipogranulomatosis

Mouse Phenotypes

increased macrophage derived foam cell number

abnormal thymus morphology

enlarged thymus

enlarged spleen

increased spleen weight

decreased double-positive T cell number

increased eosinophil cell number

increased erythrocyte cell number

increased hemoglobin content

decreased mean corpuscular hemoglobin

decreased mean corpuscular volume

increased neutrophil cell number

increased granulocyte number

decreased B cell number

decreased CD4-positive, alpha-beta T cell number

decreased CD8-positive, alpha-beta T cell number

decreased T cell number

decreased lymphocyte cell number

increased macrophage cell number

increased monocyte cell number

decreased leukocyte cell number

increased leukocyte cell number

increased hematopoietic stem cell number

decreased splenocyte number

pale spleen

Availability

Mouse Genotype

Asah1^tm1.2Geno/Asah1^tm1.2Geno

Asah1^tm1Medin/Asah1^tm1Medin

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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