|
Symbol Name ID |
Casp8
caspase 8 MGI:1261423 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Reduced CD95-induced lymphocyte apoptosis |
Decreased circulating IgA level |
Decreased circulating IgG level |
Decreased circulating total IgM |
Complete or near-complete absence of specific antibody response to unconjugated pneumococcus vaccine |
Defective B cell activation |
Decreased T cell activation |
Decreased CD4:CD8 ratio |
Splenomegaly |
Hepatosplenomegaly |
| Disease(s) Associated with CASP8 | ||||||||||
| autoimmune lymphoproliferative syndrome type 2B | ||||||||||
| pancreatic cancer |
| Mouse Phenotypes | hematopoietic system phenotype |
decreased T cell apoptosis |
abnormal macrophage differentiation |
decreased B cell proliferation |
abnormal T cell proliferation |
decreased T cell proliferation |
abnormal embryonic hematopoiesis |
enlarged spleen |
abnormal hematopoietic system morphology/development |
abnormal blood cell morphology/development |
impaired hematopoiesis |
abnormal myeloblast morphology/development |
increased erythrocyte cell number |
increased mast cell number |
decreased B-1 B cell number |
decreased marginal zone B cell number |
decreased B cell number |
increased B cell number |
abnormal T cell subpopulation ratio |
increased effector memory CD4-positive, alpha-beta T cell number |
decreased CD4-positive, alpha-beta T cell number |
increased effector memory CD8-positive, alpha-beta T cell number |
decreased CD8-positive, naive alpha-beta T cell number |
decreased CD8-positive, alpha-beta T cell number |
increased CD8-positive, alpha-beta T cell number |
decreased T cell number |
increased T cell number |
increased lymphocyte cell number |
decreased leukocyte cell number |
abnormal lymphocyte morphology |
abnormal T cell morphology |
spleen hypoplasia |
abnormal immunoglobulin level |
increased IgE level |
increased IgG1 level |
abnormal T cell physiology |
abnormal CD8-positive, alpha-beta T cell physiology |
abnormal T cell activation |
|
| Availability | Mouse Genotype | ||||||||||||||||||||||||||||||||||||||
| Casp8em1Hbz/Casp8em1Hbz | * | ||||||||||||||||||||||||||||||||||||||
| Casp8kuche/Casp8kuche | |||||||||||||||||||||||||||||||||||||||
| Casp8m1Btlr/Casp8m1Btlr | |||||||||||||||||||||||||||||||||||||||
| Casp8M2Btlr/Casp8M2Btlr | |||||||||||||||||||||||||||||||||||||||
| Casp8tm1.1Yuan/Casp8tm1.1Yuan | |||||||||||||||||||||||||||||||||||||||
| Casp8tm1Syon/Casp8tm1Syon | |||||||||||||||||||||||||||||||||||||||
| Casp8tm1Yuan/Casp8tm1Yuan | |||||||||||||||||||||||||||||||||||||||
| Casp8tm1Hed/Casp8tm1Hed Cd19tm1(cre)Cgn/Cd19+ (conditional) |
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| Casp8tm1Hed/Casp8tm1Hed Tg(KRT14-cre)1Efu/0 (conditional) |
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| Casp8tm1Raz/Casp8tm1Raz Tg(Lck-cre)548Jxm/0 (conditional) |
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| Casp8tm1Wll/Casp8tm1.1Yuan Tg(Mx1-cre)1Cgn/0 (conditional) |
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| Casp8tm1Wll/Casp8tm1.1Yuan Tg(Tie1-cre)9Ref/0 (conditional) |
* | ||||||||||||||||||||||||||||||||||||||
| Casp8tm1Wll/Casp8tm1.1Yuan Lyz2tm1(cre)Ifo/Lyz2+ (conditional) |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/21/2024 MGI 6.23 |
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