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Symbol
Name
ID 		Etv6
ets variant 6
MGI:109336
Phenotype annotations related to hematopoietic system
*Aspects of the system are reported to show a normal phenotype.
Darker colors indicate more annotations
Human Phenotypes
Increased circulating IgA level
Increased circulating IgE level
Epistaxis
Joint hemorrhage
Persistent bleeding after trauma
Bruising susceptibility
Petechiae
Abnormal megakaryocyte morphology
Increased megakaryocyte colony forming unit count
Anemia of inadequate production
Poikilocytosis
Acanthocytosis
Leukocytosis
Acute myeloid leukemia
Thrombocytopenia
Congenital thrombocytopenia
Intermittent thrombocytopenia
Abnormal platelet shape
Abnormal platelet volume
Decreased mean platelet volume
Myelodysplasia
Disease(s) Associated with ETV6
acute myeloid leukemia
myelodysplastic syndrome
thrombocytopenia

Mouse Phenotypes
hematopoietic system phenotype
abnormal megakaryocyte differentiation
increased spleen weight
abnormal hemopoiesis
abnormal definitive hematopoiesis
abnormal common myeloid progenitor cell morphology
abnormal erythropoiesis
abnormal lymphopoiesis
abnormal B cell differentiation
decreased pro-B cell number
arrested B cell differentiation
myeloid hyperplasia
abnormal common lymphocyte progenitor cell morphology
decreased erythroid progenitor cell number
abnormal myeloblast morphology/development
decreased erythrocyte cell number
decreased neutrophil cell number
thrombocytopenia
abnormal platelet shape
abnormal B cell number
decreased B cell number
decreased pre-B cell number
decreased lymphocyte cell number
increased large unstained cell number
increased hematopoietic stem cell number
abnormal hematopoietic precursor cell morphology
abnormal bone marrow cell physiology
Availability Mouse Genotype
Etv6tm2.1Sho/Etv6tm2.1Sho
Etv6em1(IMPC)Rbrc/Etv6+
Etv6em3Knic/Etv6+ *
Etv6tm2Sho/Etv6tm2Sho
Tg(Gata1-cre)1Sho/?  (conditional)
Etv6tm2Sho/Etv6tm2Sho
Tg(Mx1-cre)1Cgn/?  (conditional)
Etv6tm1(RUNX1)Haho/Etv6+
Tg(Gata1-cre)1Sho/0  (conditional)
Etv6tm1(RUNX1)Haho/Etv6+
Tg(Mx1-cre)1Cgn/0  (conditional)
Etv6tm1(RUNX1)Haho/Etv6+
Tg(VAV1-cre)1Graf/0  (conditional)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/21/2024
MGI 6.23 		The Jackson Laboratory