|
Symbol Name ID |
Hfe
homeostatic iron regulator MGI:109191 |
| Darker colors indicate more annotations |
| Human Phenotypes | Increased circulating IgA level |
Increased circulating IgG level |
Decreased circulating antibody level |
Paraproteinemia |
Abnormal bleeding |
Gastrointestinal hemorrhage |
Cerebral hemorrhage |
Purpura |
Increased megakaryocyte count |
Myelofibrosis |
Abnormal erythrocyte enzyme concentration or activity |
Increased hematocrit |
Abnormal hemoglobin |
Reduced beta/alpha synthesis ratio |
Increased circulating hemoglobin concentration |
Anemia |
Hypochromic microcytic anemia |
Microcytic anemia |
Increased red blood cell mass |
Leukocytosis |
Hemophagocytosis |
Acute lymphoblastic leukemia |
T-cell acute lymphoblastic leukemias |
Myeloproliferative disorder |
Abnormal thrombosis |
Thromboembolism |
Venous thrombosis |
Thrombocytopenia |
Thrombocytosis |
Extramedullary hematopoiesis |
Hematological neoplasm |
Lymphoma |
Multiple myeloma |
Myelodysplasia |
Elevated erythrocyte sedimentation rate |
Splenomegaly |
Hepatosplenomegaly |
| Disease(s) Associated with HFE | |||||||||||||||||||||||||||||||||||||
| acute lymphoblastic leukemia | |||||||||||||||||||||||||||||||||||||
| beta thalassemia | |||||||||||||||||||||||||||||||||||||
| cystic fibrosis | |||||||||||||||||||||||||||||||||||||
| hemochromatosis | |||||||||||||||||||||||||||||||||||||
| hemochromatosis type 1 | |||||||||||||||||||||||||||||||||||||
| multiple myeloma | |||||||||||||||||||||||||||||||||||||
| myelodysplastic syndrome | |||||||||||||||||||||||||||||||||||||
| myelofibrosis | |||||||||||||||||||||||||||||||||||||
| polycythemia vera | |||||||||||||||||||||||||||||||||||||
| porphyria cutanea tarda | |||||||||||||||||||||||||||||||||||||
| rheumatoid arthritis |
| Mouse Phenotypes | hypochromic microcytic anemia |
increased osteoclast cell number |
decreased spleen iron level |
increased spleen iron level |
|
| Availability | Mouse Genotype | ||||
| Hfetm1.1Wsr/Hfetm1.1Wsr | |||||
| Hfetm1Gfn/Hfetm1Gfn | |||||
| Hfetm2Nca/Hfetm2Nca | |||||
| Hfetm2Nca/Hfetm2Nca Tg(Ttr-Hfe)1Nca/0 |
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| Hfetm1Wsr/Hfetm1Wsr Tg(Alb1-cre)7Gsc/? (conditional) |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/21/2024 MGI 6.23 |
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