Symbol
Name
ID

Il18
interleukin 18
MGI:107936

Phenotype annotations related to hematopoietic system

Darker colors indicate more annotations

Human Phenotypes	Epistaxis	Arterial thrombosis	Superficial thrombophlebitis	Prolonged prothrombin time	Abnormality of thrombocytes	Elevated erythrocyte sedimentation rate	Splenomegaly
Disease(s) Associated with IL18	Epistaxis	Arterial thrombosis	Superficial thrombophlebitis	Prolonged prothrombin time	Abnormality of thrombocytes	Elevated erythrocyte sedimentation rate	Splenomegaly
Behcet's disease
biliary atresia
temporal arteritis

Mouse Phenotypes

impaired neutrophil chemotaxis

enlarged spleen

increased neutrophil cell number

increased dendritic cell number

increased NK cell number

decreased T cell number

increased macrophage cell number

abnormal T cell morphology

abnormal microglial cell morphology

abnormal spleen morphology

increased IgE level

increased IgG1 level

impaired natural killer cell mediated cytotoxicity

abnormal T cell physiology

abnormal T-helper 1 physiology

abnormal macrophage physiology

Availability

Mouse Genotype

Il18^tm1Aki/Il18^tm1Aki

Il18^tm1Khe/Il18^tm1Khe

Tg(KRT14-Il18)#Knak/0

Tg(SFTPC-Il18)AThos/0

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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