Symbol
Name
ID

Lyst
lysosomal trafficking regulator
MGI:107448

Phenotype annotations related to hematopoietic system

Darker colors indicate more annotations

Human Phenotypes

Abnormal bleeding

Epistaxis

Spontaneous, recurrent epistaxis

Gingival bleeding

Bruising susceptibility

Abnormality of multiple cell lineages in the bone marrow

Pancytopenia

Anemia

Abnormal leukocyte morphology

Neutropenia

Leukopenia

Abnormal natural killer cell morphology

Vacuolated lymphocytes

Increased proportion of CD25+ mast cells

Giant neutrophil granules

Abnormality of neutrophil physiology

Impaired neutrophil bactericidal activity

Hemophagocytosis

Hypofibrinogenemia

Abnormal platelet function

Thrombocytopenia

Abnormal dense granules

Splenomegaly

Hepatosplenomegaly

Disease(s) Associated with LYST

Chediak-Higashi syndrome

Mouse Phenotypes

decreased platelet ATP level

impaired macrophage phagocytosis

abnormal eosinophil morphology

increased mean corpuscular hemoglobin

increased mean corpuscular volume

abnormal granulocyte morphology

abnormal dermal mast cell morphology

abnormal neutrophil morphology

decreased platelet ADP level

decreased platelet serotonin level

absent NK T cells

decreased macrophage cell number

abnormal lymphocyte morphology

abnormal NK cell physiology

impaired natural killer cell mediated cytotoxicity

decreased cytotoxic T cell cytolysis

Availability

Mouse Genotype

Lyst^bg-2Btlr/Lyst^bg-2Btlr

Lyst^bg-5Btlr/Lyst^bg-5Btlr

Lyst^bg-Btlr/Lyst^bg-Btlr

Lyst^bg-grey/Lyst^bg-grey

Lyst^bg-J/Lyst^bg-J

Lyst^bg-Lac/Lyst^bg-Lac

Lyst^bg/Lyst^bg

Lyst^{tm1b(EUCOMM)Wtsi}/Lyst^{tm1b(EUCOMM)Wtsi}

Lyst^bg-5Btlr/Lyst⁺

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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