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Symbol
Name
ID

Ccr2
C-C motif chemokine receptor 2
MGI:106185

Phenotype annotations related to hematopoietic system

Darker colors indicate more annotations

Human Phenotypes	Anemia	Hemolytic anemia	Eosinophilia	Increased T cell count	Leukopenia	Thrombocytopenia
Disease(s) Associated with CCR2
sarcoidosis

Mouse Phenotypes

abnormal osteoclast differentiation

abnormal dendritic cell chemotaxis

abnormal macrophage chemotaxis

impaired macrophage chemotaxis

abnormal leukocyte migration

abnormal cellular extravasation

impaired leukocyte tethering or rolling

abnormal leukocyte adhesion

decreased T cell proliferation

decreased splenocyte proliferation

enlarged spleen

decreased common myeloid progenitor cell number

increased eosinophil cell number

decreased neutrophil cell number

decreased CD11b-high dendritic cell number

increased CD11b-high dendritic cell number

increased dendritic cell number

increased B cell number

decreased CD4-positive, alpha-beta T cell number

increased CD8-positive, alpha-beta T cell number

decreased lymphocyte cell number

decreased macrophage cell number

decreased osteoclast cell number

decreased monocyte cell number

abnormal macrophage morphology

abnormal osteoclast cell number

abnormal monocyte morphology

abnormal spleen morphology

abnormal leukocyte physiology

increased IgG level

abnormal microglial cell physiology

abnormal osteoclast physiology

Availability

Mouse Genotype

Ccr2^em1(IMPC)H/Ccr2^em1(IMPC)H

Ccr2^{tm1.1(CCR2)Rodb}/Ccr2^{tm1.1(CCR2)Rodb}

Ccr2^tm1.1Dnc/Ccr2^tm1.1Dnc

Ccr2^tm1.1Mpa/Ccr2^tm1.1Mpa

Ccr2^tm1Blck/Ccr2^tm1Blck

Ccr2^tm1Brv/Ccr2^tm1Brv

Ccr2^tm1Ifc/Ccr2^tm1Ifc

Ccr2^tm1Mae/Ccr2^tm1Mae

Ccr2^tm1Ifc/Ccr2⁺

Ccr2^tm1Mpa/Ccr2^tm1Mpa
Lyz2^tm1(cre)Ifo/Lyz2⁺ (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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