Symbol
Name
ID

Npm1
nucleophosmin 1
MGI:106184

Phenotype annotations related to hematopoietic system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Acute myeloid leukemia
Disease(s) Associated with NPM1	Acute myeloid leukemia
acute myeloid leukemia

Mouse Phenotypes

hematopoietic system phenotype

abnormal granulocyte differentiation

abnormal embryonic hematopoiesis

enlarged spleen

increased spleen weight

abnormal common myeloid progenitor cell morphology

abnormal thrombopoiesis

myeloid hyperplasia

extramedullary hematopoiesis

anemia

abnormal bone marrow cell morphology/development

increased bone marrow cell number

abnormal bone marrow hematopoietic cell morphology

increased granulocyte monocyte progenitor cell number

abnormal megakaryocyte morphology

abnormal proerythroblast morphology

increased mean corpuscular volume

anisocytosis

increased granulocyte number

thrombocytosis

increased mean platelet volume

decreased B cell number

increased monocyte cell number

increased leukocyte cell number

reticulocytopenia

decreased hematopoietic stem cell number

increased hematopoietic stem cell number

abnormal spleen B cell follicle morphology

abnormal bone marrow cell physiology

abnormal hematopoietic stem cell physiology

Availability

Mouse Genotype

Npm1^tm1Ppp/Npm1^tm1Ppp

Npm1^tm2Ppp/Npm1^tm2Ppp

Npm1^{Gt(OST331547)Lex}/Npm1⁺

Npm1^tm1Hft/Npm1⁺

Npm1^tm1Ppp/Npm1⁺

Gt(ROSA)26Sor^{tm3(CAG-flpo/ERT2)Alj}/Gt(ROSA)26Sor⁺
Npm1^tm1Trow/Npm1⁺ (conditional)

Npm1^tm1Gsva/Npm1⁺
Tg(Mx1-cre)1Cgn/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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