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Symbol
Name
ID

Pdcd1
programmed cell death 1
MGI:104879

Phenotype annotations related to hematopoietic system

Darker colors indicate more annotations

Human Phenotypes	Increased circulating IgA concentration	Abnormal circulating IgE concentration	Increased circulating IgG concentration	Abnormal circulating IgM concentration	Diffuse alveolar hemorrhage	Bone marrow hypocellularity	Hemolytic anemia	Decreased total leukocyte count	Thrombocytopenia	Splenomegaly
Disease(s) Associated with PDCD1	Increased circulating IgA concentration	Abnormal circulating IgE concentration	Increased circulating IgG concentration	Abnormal circulating IgM concentration	Diffuse alveolar hemorrhage	Bone marrow hypocellularity	Hemolytic anemia	Decreased total leukocyte count	Thrombocytopenia	Splenomegaly
infantile onset multisystem autoimmune disease 4
systemic lupus erythematosus

Mouse Phenotypes

increased B cell proliferation

enlarged spleen

abnormal leukopoiesis

abnormal myelopoiesis

decreased B-1 B cell number

increased B-1 B cell number

increased B cell number

increased T-helper 1 cell number

decreased CD8-positive, alpha-beta T cell number

decreased regulatory T cell number

increased regulatory T cell number

increased lymphocyte cell number

abnormal immunoglobulin level

increased IgA level

increased IgG2b level

increased IgG3 level

increased IgM level

abnormal T cell activation

Availability

Mouse Genotype

Pdcd1^tm1.1Liux/Pdcd1^tm1.1Liux

Pdcd1^tm1.1Shr/Pdcd1^tm1.1Shr

Pdcd1^tm1Hon/Pdcd1^tm1Hon

Pdcd1^tm1Llc/Pdcd1^tm1Llc

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 03/31/2026 MGI 6.24