Symbol
Name
ID

Tnf
tumor necrosis factor
MGI:104798

Phenotype annotations related to hematopoietic system

Darker colors indicate more annotations

Human Phenotypes

Increased circulating IgA level

Increased circulating IgE level

Increased circulating IgG level

Polyclonal elevation of IgM

Decreased circulating antibody level

Increased circulating antibody level

Paraproteinemia

Abnormality of blood and blood-forming tissues

Abnormal bleeding

Epistaxis

Gingival bleeding

Joint hemorrhage

Persistent bleeding after trauma

Bruising susceptibility

Petechiae

Abnormal bone marrow cell morphology

Abnormal megakaryocyte morphology

Increased megakaryocyte colony forming unit count

Bone marrow hypocellularity

Pancytopenia

Aplastic anemia

Abnormal hemoglobin

Reduced beta/alpha synthesis ratio

Decreased mean corpuscular volume

Erythroid hyperplasia

Anemia

Hemolytic anemia

Anemia of inadequate production

Hypochromic microcytic anemia

Microcytic anemia

Sideroblastic anemia

Hypochromia

Poikilocytosis

Acanthocytosis

Leukocytosis

Leukopenia

Venous thrombosis

Superficial thrombophlebitis

Abnormality of coagulation

Thrombocytopenia

Congenital thrombocytopenia

Intermittent thrombocytopenia

Abnormal platelet shape

Abnormal platelet volume

Decreased mean platelet volume

Multiple myeloma

Elevated erythrocyte sedimentation rate

Abnormality of the spleen

Splenic infarction

Splenic rupture

Splenomegaly

Hepatosplenomegaly

Disease(s) Associated with TNF

aplastic anemia

Behcet's disease

beta thalassemia

cystic fibrosis

Gaucher's disease

hemochromatosis

hypochromic microcytic anemia

leprosy

malaria

multiple myeloma

pre-eclampsia

rheumatoid arthritis

systemic lupus erythematosus

thrombocytopenia

Mouse Phenotypes

impaired macrophage phagocytosis

thymus hypoplasia

enlarged spleen

increased spleen weight

abnormal class switch recombination

abnormal myelopoiesis

increased neutrophil cell number

abnormal platelet cell number

increased dendritic cell number

absent germinal center B cells

increased B cell number

abnormal T cell subpopulation ratio

increased CD4-positive, alpha-beta memory T cell number

increased CD4-positive, alpha-beta T cell number

decreased CD8-positive, alpha-beta T cell number

increased CD8-positive, alpha-beta T cell number

decreased T cell number

increased lymphocyte cell number

increased leukocyte cell number

abnormal dendritic cell morphology

abnormal B cell morphology

abnormal T cell morphology

abnormal CD4-positive, alpha beta T cell morphology

abnormal CD8-positive, alpha beta T cell morphology

abnormal alpha-beta intraepithelial T cell morphology

abnormal gamma-delta T cell morphology

abnormal metallophilic macrophage morphology

abnormal microglial cell morphology

abnormal spleen morphology

intermingled spleen red and white pulp

abnormal spleen white pulp morphology

abnormal spleen B cell follicle morphology

decreased spleen B cell follicle number

abnormal spleen follicular dendritic cell network

abnormal spleen primary B follicle morphology

absent spleen germinal center

decreased spleen germinal center number

decreased spleen germinal center size

abnormal spleen marginal sinus morphology

abnormal spleen marginal zone morphology

absent spleen marginal zone

decreased spleen white pulp amount

abnormal neutrophil physiology

abnormal lymphocyte physiology

decreased IgA level

decreased IgG1 level

decreased IgG2a level

decreased IgG3 level

decreased IgG level

increased IgM level

decreased immunoglobulin level

abnormal T cell physiology

abnormal CD4-positive, alpha-beta T cell physiology

abnormal T-helper 17 cell physiology

abnormal cytotoxic T cell physiology

abnormal macrophage physiology

decreased macrophage cytokine production

Availability

Mouse Genotype

Lta/Tnf^tm1Eug/Lta/Tnf^tm1Eug

Lta/Tnf^tm1Jods/Lta/Tnf^tm1Jods

Ltb/Tnf/Lta^tm1Dvk/Ltb/Tnf/Lta^tm1Dvk

Ltb/Tnf^tm1.1Dvk/Ltb/Tnf^tm1.1Dvk

Tnf^tm1.2Sned/Tnf^tm1.2Sned

Tnf^tm1Gkl/Tnf^tm1Gkl

Tnf^tm1Jods/Tnf^tm1Jods

Tnf^tm1Ljo/Tnf^tm1Ljo

Tnf^tm1Sek/Tnf^tm1Sek

Tnf^tm2Gkl/Tnf^tm2Gkl

Tnf^tm2Jods/Tnf^tm2Jods

Tnf^tm3Gkl/Tnf^tm3Gkl

Tnf^M2Btlr/Tnf⁺

Tnf^tm2Gkl/Tnf⁺

Tg(Ins2-Tnf)17Flv/0

Tg(SFTPC-rtTA,tetO-Tnf)320-1Gwho/0

Tg(SFTPC-Tnf)2Pva/0

Tg(Tnf)6074Gkl/0

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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