|
Symbol Name ID |
Stat1
signal transducer and activator of transcription 1 MGI:103063 |
| Darker colors indicate more annotations |
| Human Phenotypes | Autoimmune hemolytic anemia |
Neutropenia in presence of anti-neutropil antibodies |
B lymphocytopenia |
Lymphopenia |
Thrombocytopenia |
Autoimmune thrombocytopenia |
Hepatosplenomegaly |
| Disease(s) Associated with STAT1 | |||||||
| immunodeficiency 31C |
| Mouse Phenotypes | abnormal osteoclast differentiation |
decreased NK cell degranulation |
abnormal common myeloid progenitor cell morphology |
abnormal T cell differentiation |
abnormal CD4-positive T cell differentiation |
abnormal CD8-positive, alpha-beta T cell differentiation |
increased basophil cell number |
increased eosinophil cell number |
decreased mean corpuscular hemoglobin |
decreased mean corpuscular volume |
increased neutrophil cell number |
decreased B-1 B cell number |
decreased B cell number |
decreased NK cell number |
increased effector memory CD4-positive, alpha-beta T cell number |
increased CD4-positive, alpha-beta T cell number |
increased effector memory CD8-positive, alpha-beta T cell number |
abnormal CD8-positive, naive alpha-beta T cell number |
decreased CD8-positive, naive alpha-beta T cell number |
decreased CD8-positive, alpha-beta T cell number |
increased NK T cell number |
decreased single-positive T cell number |
increased T cell number |
decreased lymphocyte cell number |
increased lymphocyte cell number |
increased large unstained cell number |
increased osteoclast cell number |
increased monocyte cell number |
increased leukocyte cell number |
abnormal leukocyte physiology |
increased IgG level |
abnormal NK cell physiology |
impaired natural killer cell mediated cytotoxicity |
abnormal T-helper 2 physiology |
decreased cytotoxic T cell cytolysis |
abnormal T cell activation |
abnormal macrophage physiology |
abnormal MHC II cell surface expression on macrophages |
increased macrophage nitric oxide production |
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| Availability | Mouse Genotype | |||||||||||||||||||||||||||||||||||||||
| Stat1fae/Stat1fae | ||||||||||||||||||||||||||||||||||||||||
| Stat1m1Btlr/Stat1m1Btlr | ||||||||||||||||||||||||||||||||||||||||
| Stat1m2Btlr/Stat1m2Btlr | ||||||||||||||||||||||||||||||||||||||||
| Stat1m3Btlr/Stat1m3Btlr | ||||||||||||||||||||||||||||||||||||||||
| Stat1m4Btlr/Stat1m4Btlr | ||||||||||||||||||||||||||||||||||||||||
| Stat1m5Btlr/Stat1m5Btlr | ||||||||||||||||||||||||||||||||||||||||
| Stat1tm1Dlv/Stat1tm1Dlv | ||||||||||||||||||||||||||||||||||||||||
| Stat1tm1Rds/Stat1tm1Rds | ||||||||||||||||||||||||||||||||||||||||
| Stat1tm1Tdec/Stat1tm1Tdec | ||||||||||||||||||||||||||||||||||||||||
| Stat1tm1Uvin/Stat1tm1Uvin | ||||||||||||||||||||||||||||||||||||||||
| Stat1tm2b(EUCOMM)Wtsi/Stat1tm2b(EUCOMM)Wtsi | ||||||||||||||||||||||||||||||||||||||||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/14/2024 MGI 6.23 |
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