|
Symbol Name ID |
Thrb
thyroid hormone receptor beta MGI:98743 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Hearing impairment |
| Disease(s) Associated with THRB | |
| thyroid hormone resistance syndrome |
| Mouse Phenotypes | hearing/vestibular/ear phenotype |
delayed inner ear development |
abnormal cochlea morphology |
decreased cochlear outer hair cell number |
cochlear outer hair cell degeneration |
short cochlear outer hair cells |
cochlear hair cell degeneration |
abnormal organ of Corti morphology |
abnormal pillar cell morphology |
degeneration of organ of Corti supporting cells |
organ of Corti degeneration |
spiral ligament degeneration |
abnormal tectorial membrane morphology |
abnormal tectorial membrane striated-sheet matrix morphology |
detached tectorial membrane |
enlarged tectorial membrane |
abnormal cochlear inner hair cell physiology |
abnormal cochlear outer hair cell physiology |
decreased cochlear microphonics |
decreased cochlear outer hair cell electromotility |
increased or absent threshold for auditory brainstem response |
abnormal cochlear nerve compound action potential |
increased or absent distortion product otoacoustic emission threshold |
absent distortion product otoacoustic emissions |
impaired hearing |
deafness |
sensorineural hearing loss |
|
| Availability | Mouse Genotype | |||||||||||||||||||||||||||
| Thrbtm1.1Syc/Thrbtm1.1Syc | ||||||||||||||||||||||||||||
| Thrbtm1Df/Thrbtm1Df | ||||||||||||||||||||||||||||
| Thrbtm1Few/Thrbtm1Few | * | |||||||||||||||||||||||||||
| Thrbtm2Df/Thrbtm2Df | * | |||||||||||||||||||||||||||
| Thrbtm3Few/Thrbtm3Few | ||||||||||||||||||||||||||||
| Thrbtm4Few/Thrbtm4Few | ||||||||||||||||||||||||||||
| Thrbtm1.1Syc/Thrb+ | * | |||||||||||||||||||||||||||
| Thrbtm1Df/Thrbtm1Mkni Tg(Pres-cre)1Jnz/0 (conditional) |
||||||||||||||||||||||||||||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
|
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 05/14/2024 MGI 6.23 |
|
|
|
||
Analysis Tools