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Symbol Name ID |
Fgfr1
fibroblast growth factor receptor 1 MGI:95522 |
| * | Aspects of the system are reported to show a normal phenotype. |
| ! | Indicates phenotype varies with strain background. |
| Darker colors indicate more annotations |
| Human Phenotypes | Chronic otitis media |
Low-set ears |
Protruding ear |
Sensorineural hearing impairment |
Hearing impairment |
| Disease(s) Associated with FGFR1 | |||||
| acrocephalosyndactylia | |||||
| hypogonadotropic hypogonadism 2 with or without anosmia | |||||
| osteoglophonic dysplasia |
| Mouse Phenotypes | hearing/vestibular/ear phenotype |
absent round window |
decreased round window size |
abnormal middle ear ossicle morphology |
abnormal incus morphology |
abnormal incus body morphology |
absent incus lenticular process |
abnormal incus long process morphology |
abnormal incus short process morphology |
incus hypoplasia |
abnormal malleus morphology |
absent gonial bone |
small gonial bone |
malleus hypoplasia |
abnormal stapes morphology |
abnormal stapes posterior crus morphology |
absent stapes head |
stapes hypoplasia |
absent middle ear ossicles |
middle ear ossicle hypoplasia |
abnormal outer ear morphology |
abnormal ear position |
lowered ear position |
abnormal ear shape |
excessive cerumen |
small ears |
abnormal auditory bulla morphology |
abnormal cochlear hair cell development |
abnormal inner ear morphology |
abnormal cochlea morphology |
abnormal cochlear sensory epithelium morphology |
abnormal cochlear hair cell morphology |
decreased cochlear hair cell number |
decreased cochlear outer hair cell number |
absent cochlear outer hair cells |
increased cochlear inner hair cell number |
abnormal orientation of inner hair cell stereociliary bundles |
abnormal organ of Corti morphology |
absent organ of Corti supporting cells |
abnormal middle ear morphology |
absent tympanic ring |
decreased tympanic ring size |
tympanic ring hypoplasia |
abnormal ear physiology |
decreased endocochlear potential |
increased or absent threshold for auditory brainstem response |
abnormal cochlear nerve compound action potential |
increased susceptibility to otitis media |
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| Availability | Mouse Genotype | ||||||||||||||||||||||||||||||||||||||||||||||||
| Fgfr1tm2Jrt/Fgfr1tm2Jrt | |||||||||||||||||||||||||||||||||||||||||||||||||
| Fgfr1tm4.1Jrt/Fgfr1tm4.1Jrt | * | ||||||||||||||||||||||||||||||||||||||||||||||||
| Fgfr1tm6Jrt/Fgfr1tm6Jrt | |||||||||||||||||||||||||||||||||||||||||||||||||
| Fgfr1tm9.1Sor/Fgfr1tm9.1Sor | |||||||||||||||||||||||||||||||||||||||||||||||||
| Fgfr1Eask/Fgfr1+ | |||||||||||||||||||||||||||||||||||||||||||||||||
| Fgfr1Hspy/Fgfr1+ | *! | ! | ! | ! | |||||||||||||||||||||||||||||||||||||||||||||
| Fgfr1tm1Upir/Fgfr1tm1Upir Foxg1tm1(cre)Skm/Foxg1+ (conditional) |
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| Fgfr1tm2Jrt/Fgfr1tm2Jrt H2az2Tg(Wnt1-cre)11Rth/H2az2+ (conditional) |
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| Fgfr1tm1Upir/Fgfr1tm1.1Upir Foxg1tm1(cre)Skm/Foxg1+ (conditional) |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/28/2024 MGI 6.13 |
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