Symbol Name ID |
Atp2b2
ATPase, Ca++ transporting, plasma membrane 2 MGI:105368 |
* | Aspects of the system are reported to show a normal phenotype. |
! | Indicates phenotype varies with strain background. |
Darker colors indicate more annotations |
Human Phenotypes | Abnormal vestibular function |
Prelingual sensorineural hearing impairment |
Disease(s) Associated with ATP2B2 | ||
autosomal recessive nonsyndromic deafness 12 |
Mouse Phenotypes | hearing/vestibular/ear phenotype |
abnormal inner ear morphology |
decreased cochlear hair cell number |
absent cochlear hair cells |
abnormal cochlear hair cell stereociliary bundle morphology |
abnormal outer hair cell stereociliary bundle morphology |
absent outer hair cell stereocilia |
cochlear inner hair cell degeneration |
cochlear outer hair cell degeneration |
cochlear hair cell degeneration |
abnormal organ of Corti morphology |
decreased organ of Corti supporting cell number |
absent organ of Corti supporting cells |
absent pillar cells |
pillar cell degeneration |
absent tunnel of Corti |
organ of Corti degeneration |
cochlear degeneration |
absent vestibular hair cells |
abnormal inner ear vestibule morphology |
abnormal vestibular saccule morphology |
vestibular saccular degeneration |
absent otoliths |
abnormal cochlear hair cell physiology |
abnormal cochlear microphonics |
abnormal hair cell mechanoelectric transduction |
abnormal vestibular hair cell physiology |
abnormal hearing physiology |
abnormal auditory brainstem response |
abnormal auditory brainstem response waveform shape |
decreased threshold for auditory brainstem response |
increased or absent threshold for auditory brainstem response |
abnormal cochlear nerve compound action potential |
abnormal distortion product otoacoustic emission |
decreased distortion product otoacoustic emission amplitude |
increased or absent distortion product otoacoustic emission threshold |
absent distortion product otoacoustic emissions |
increased susceptibility to age-related hearing loss |
increased susceptibility to noise-induced hearing loss |
impaired hearing |
deafness |
sensorineural hearing loss |
syndromic hearing loss |
abnormal vestibular system physiology |
absent linear vestibular evoked potential |
reduced linear vestibular evoked potential |
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Availability | Mouse Genotype | ||||||||||||||||||||||||||||||||||||||||||||||
Atp2b2Deaf11/Atp2b2Deaf11 | |||||||||||||||||||||||||||||||||||||||||||||||
Atp2b2Deaf13/Atp2b2Deaf13 | |||||||||||||||||||||||||||||||||||||||||||||||
Atp2b2dfw-2J/Atp2b2dfw-2J | |||||||||||||||||||||||||||||||||||||||||||||||
Atp2b2dfw-3J/Atp2b2dfw-3J | |||||||||||||||||||||||||||||||||||||||||||||||
Atp2b2dfw-i5/Atp2b2dfw-i5 | ! | ||||||||||||||||||||||||||||||||||||||||||||||
Atp2b2dfw/Atp2b2dfw | |||||||||||||||||||||||||||||||||||||||||||||||
Atp2b2Elfin/Atp2b2Elfin | |||||||||||||||||||||||||||||||||||||||||||||||
Atp2b2Obv/Atp2b2Obv | |||||||||||||||||||||||||||||||||||||||||||||||
Atp2b2tm1Ges/Atp2b2tm1Ges | |||||||||||||||||||||||||||||||||||||||||||||||
Atp2b2Tmy/Atp2b2Tmy | |||||||||||||||||||||||||||||||||||||||||||||||
Atp2b2wri/Atp2b2wri | |||||||||||||||||||||||||||||||||||||||||||||||
Atp2b2Deaf11/Atp2b2+ | |||||||||||||||||||||||||||||||||||||||||||||||
Atp2b2Deaf11/Atp2b2Deaf13 | |||||||||||||||||||||||||||||||||||||||||||||||
Atp2b2Deaf13/Atp2b2+ | |||||||||||||||||||||||||||||||||||||||||||||||
Atp2b2dfw-2J/Atp2b2+ | * | ||||||||||||||||||||||||||||||||||||||||||||||
Atp2b2dfw-i5/Atp2b2+ | |||||||||||||||||||||||||||||||||||||||||||||||
Atp2b2dfw/Atp2b2+ | |||||||||||||||||||||||||||||||||||||||||||||||
Atp2b2Elfin/Atp2b2+ | |||||||||||||||||||||||||||||||||||||||||||||||
Atp2b2Obv/Atp2b2+ | |||||||||||||||||||||||||||||||||||||||||||||||
Atp2b2tm1Ges/Atp2b2+ | ! | ! | |||||||||||||||||||||||||||||||||||||||||||||
Atp2b2Tmy/Atp2b2+ | * | ||||||||||||||||||||||||||||||||||||||||||||||
Atp2b2wri/Atp2b2+ |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/14/2024 MGI 6.23 |
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