Symbol
Name
ID

Hnf1b
HNF1 homeobox B
MGI:98505

Phenotype annotations related to endocrine/exocrine glands

Darker colors indicate more annotations

Human Phenotypes	Diabetes mellitus	Maturity-onset diabetes of the young	Type II diabetes mellitus	Pancreatic hypoplasia	Pancreatic atrophy	Exocrine pancreatic insufficiency
Disease(s) Associated with HNF1B	Diabetes mellitus	Maturity-onset diabetes of the young	Type II diabetes mellitus	Pancreatic hypoplasia	Pancreatic atrophy	Exocrine pancreatic insufficiency
maturity-onset diabetes of the young type 5
type 2 diabetes mellitus

Mouse Phenotypes

decreased pancreatic acinar cell number

pancreatic acinar hypoplasia

abnormal pancreatic duct morphology

abnormal extrahepatic bile duct morphology

abnormal cystic duct morphology

abnormal intrahepatic bile duct morphology

abnormal interlobular bile duct morphology

decreased pancreatic islet number

small pancreatic islets

abnormal gallbladder epithelium morphology

pancreas fibrosis

pancreas lipomatosis

pancreatic acinar-to-ductal metaplasia

decreased insulin secretion

chronic pancreas inflammation

Availability

Mouse Genotype

Hnf1b^tm2Ics/Hnf1b⁺

Hnf1b^tm1Mya/Hnf1b^tm3Mya
Tg(Alb1-cre)7Gsc/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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