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Symbol Name ID |
Nf1
neurofibromin 1 MGI:97306 |
| Darker colors indicate more annotations |
| Human Phenotypes | Abnormality of the endocrine system |
Increased serum serotonin |
Parathyroid adenoma |
Carcinoid tumor |
Pheochromocytoma |
Delayed puberty |
Precocious puberty |
| Disease(s) Associated with NF1 | |||||||
| autistic disorder | |||||||
| neurofibromatosis 1 |
| Mouse Phenotypes | abnormal adrenal gland morphology |
abnormal adrenal cortex morphology |
thin adrenal cortex |
abnormal adrenergic chromaffin cell morphology |
adrenal medulla hyperplasia |
enlarged adrenal glands |
abnormal pituitary gland morphology |
small adenohypophysis |
abnormal pituitary gland development |
small pituitary gland |
abnormal seminiferous tubule epithelium morphology |
abnormal Sertoli cell barrier morphology |
seminiferous tubule degeneration |
decreased Leydig cell number |
enlarged testis |
increased adrenal gland tumor incidence |
increased pheochromocytoma incidence |
abnormal pituitary gland physiology |
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| Availability | Mouse Genotype | ||||||||||||||||||
| Nf1Mhdadsk9/Nf1+ | |||||||||||||||||||
| Nf1tm1Tyj/Nf1+ | |||||||||||||||||||
| Nf1tm1Par/Nf1tm1Par Tg(Mpz-cre)94Imeg/0 (conditional) |
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| Nf1tm1Par/Nf1tm1Par Tg(Pax3-cre)1Joe/0 (conditional) |
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| Nf1tm1Par/Nf1tm1Par H2az2Tg(Wnt1-cre)11Rth/H2az2+ (conditional) |
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| Nf1tm1Par/Nf1tm1Par Tg(Fabp7-cre,-lacZ)3Gtm/0 (conditional) |
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| Nf1tm1Fcr/Nf1tm1Par Pax3tm1(cre)Joe/Pax3+ (conditional) |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/14/2024 MGI 6.23 |
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