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Symbol Name ID |
Kras
Kirsten rat sarcoma viral oncogene homolog MGI:96680 |
| * | Aspects of the system are reported to show a normal phenotype. |
| ! | Indicates phenotype varies with strain background. |
| Darker colors indicate more annotations |
| Human Phenotypes | Diabetes mellitus |
Exocrine pancreatic insufficiency |
Neoplasm of the pancreas |
Pancreatic adenocarcinoma |
Pituitary adenoma |
Pineal cyst |
Neoplasm of the thyroid gland |
Delayed menarche |
Precocious puberty |
Hypogonadotropic hypogonadism |
| Disease(s) Associated with KRAS | ||||||||||
| linear nevus sebaceous syndrome | ||||||||||
| Lynch syndrome | ||||||||||
| Noonan syndrome | ||||||||||
| oculoectodermal syndrome | ||||||||||
| pancreatic cancer |
| Mouse Phenotypes | abnormal colon goblet cell morphology |
abnormal pancreatic acinar cell morphology |
abnormal pancreatic duct morphology |
abnormal large intestine crypts of Lieberkuhn morphology |
absent Paneth cells |
submandibular gland hyperplasia |
endocrine/exocrine gland phenotype |
enlarged pancreatic islets |
abnormal skin sebaceous gland morphology |
enlarged sebaceous gland |
sebaceous gland hyperplasia |
prostate gland hyperplasia |
Harderian gland hyperplasia |
increased pancreas weight |
enlarged pancreas |
pancreas cyst |
pancreatic acinar-to-ductal metaplasia |
abnormal ovary morphology |
increased pancreas tumor incidence |
increased pancreatic ductal adenocarcinoma incidence |
increased pancreatic intraepithelial neoplasia incidence |
increased prostate gland adenocarcinoma incidence |
increased prostate intraepithelial neoplasia incidence |
increased T cell derived lymphoma incidence |
increased lymphoblastic lymphoma incidence |
abnormal prostate gland physiology |
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| Availability | Mouse Genotype | ||||||||||||||||||||||||||
| Krastm3Tyj/Krastm3Tyj | |||||||||||||||||||||||||||
| Krastm2Tyj/Kras+ | ! | ||||||||||||||||||||||||||
| Krastm3Tyj/Kras+ | ! | ||||||||||||||||||||||||||
| Krastm1Bbd/Krastm1Bbd Tg(Cela1-tTA)#Eps/? Tg(tetO-cre)3Jig/? (conditional) |
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| Krastm4Tyj/Krastm4Tyj Tg(Cela1-cre/ERT2)1Stof/0 (conditional) |
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| Krastm4Tyj/Krastm4Tyj Bhlha15tm3(cre/ERT2)Skz/Bhlha15+ (conditional) |
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| Krastm4Tyj/Krastm4Tyj Tg(Cela1-cre/ERT)1Dam/0 (conditional) |
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| Krastm4Tyj/Krastm4Tyj Tg(Pdx1-cre/Esr1*)35.10Dam/0 (conditional) |
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| Krastm4Tyj/Krastm4Tyj Tg(Pdx1-cre)89.1Dam/0 (conditional) |
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| Krastm4Tyj/Krastm4Tyj Ptf1atm1(cre)Hnak/Ptf1a+ (conditional) |
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| Krastm4Tyj/Kras+ Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+ (conditional) |
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| Krastm1.1Khai/Kras+ Tg(Fabp1-cre)1Jig/0 (conditional) |
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| Krastm1Bbd/Kras+ Tg(CMV-cre/ERT)1Ipc/0 (conditional) |
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| Krastm1Bbd/Kras+ Tg(Pbsn-cre)4Prb/0 (conditional) |
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| Krastm4Tyj/Kras+ Tg(Pdx1-cre)6Tuv/? (conditional) |
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| Krastm4Tyj/Kras+ Ptf1atm1.1(cre)Cvw/Ptf1a+ (conditional) |
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| Krastm4Tyj/Kras+ Tg(Mx1-cre)1Cgn/0 (conditional) |
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| Krastm4Tyj/Kras+ Tg(Fabp1-cre)1Jig/0 (conditional) |
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| Krastm4Tyj/Kras+ Tg(MMTV-cre)4Mam/0 (conditional) |
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| Krastm4Tyj/Kras+ Tg(Fabp7-cre,-lacZ)3Gtm/0 (conditional) |
* | ||||||||||||||||||||||||||
| Krastm4Tyj/Kras+ (conditional) | |||||||||||||||||||||||||||
| Krastm4Tyj/Kras+ Tg(Pdx1-cre)6Tuv/0 (conditional) |
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| Krastm4Tyj/Kras+ Krt19tm1(cre/ERT)Ggu/Krt19+ (conditional) |
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| Krastm4Tyj/Kras+ Tg(Pbsn-cre)20Fwan/0 (conditional) |
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| Krastm4Tyj/Kras+ Tg(Pdx1-cre)89.1Dam/0 (conditional) |
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| Krastm4Tyj/Kras+ Tg(Cela1-cre/ERT)1Dam/0 (conditional) |
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| Krastm4Tyj/Kras+ Tg(Tg-cre/ERT2)#Mmcm/0 (conditional) |
* | ||||||||||||||||||||||||||
| Krastm4Tyj/Kras+ Tg(TPO-cre)1Shk/0 (conditional) |
* | ||||||||||||||||||||||||||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/28/2024 MGI 6.13 |
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