|
Symbol Name ID |
Gnas
GNAS complex locus MGI:95777 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Elevated circulating parathyroid hormone level |
Decreased circulating ACTH concentration |
Elevated circulating thyroid-stimulating hormone concentration |
Increased circulating cortisol level |
Primary hypercortisolism |
Adrenal hyperplasia |
Macronodular adrenal hyperplasia |
Decreased response to growth hormone stimulation test |
Pituitary resistance to thyroid hormone |
Abnormality of the parathyroid gland |
Pseudohypoparathyroidism |
Hypothyroidism |
Hypogonadism |
| Disease(s) Associated with GNAS | |||||||||||||
| ACTH-independent macronodular adrenal hyperplasia 1 | |||||||||||||
| Albright's hereditary osteodystrophy | |||||||||||||
| progressive osseous heteroplasia | |||||||||||||
| pseudohypoparathyroidism | |||||||||||||
| pseudohypoparathyroidism type IB | |||||||||||||
| pseudopseudohypoparathyroidism |
| Mouse Phenotypes | endocrine/exocrine gland phenotype |
pancreatic islet hyperplasia |
thymus cortex atrophy |
increased pancreas weight |
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| Availability | Mouse Genotype | ||||
| Gnastm1Lsw/Gnas+ | |||||
| Gnastm3Lsw/Gnastm3Lsw Tg(TPO-cre)1Shk/0 (conditional) |
* | ||||
| Gnastm5.1Lsw/Gnastm5.1Lsw Tg(Alb1-cre)1Dlr/? (conditional) |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/21/2024 MGI 6.23 |
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