Symbol
Name
ID

Sirt1
sirtuin 1
MGI:2135607

Phenotype annotations related to endocrine/exocrine glands

Darker colors indicate more annotations

Mouse Phenotypes

exocrine pancreas atrophy

abnormal salivary gland morphology

decreased pituitary gland weight

small pituitary gland

abnormal mammary gland morphology

abnormal branching of the mammary ductal tree

abnormal mammary gland growth during pregnancy

abnormal lacrimal gland morphology

absent corpus luteum

small ovary

abnormal seminiferous tubule morphology

abnormal seminiferous tubule epithelium morphology

small seminiferous tubules

abnormal Sertoli cell development

abnormal adult Leydig cell differentiation

decreased Leydig cell number

decreased testis weight

increased insulin secretion

abnormal pituitary gland physiology

hypolactation

decreased testes secretion

Availability

Mouse Genotype

Sirt1^tm1.1Ygu/Sirt1^tm1.1Ygu

Sirt1^tm1Mcby/Sirt1^tm1Mcby

Sirt1^tm3.1Mcby/Sirt1^tm3.1Mcby

Sirt1^tm3Fwa/Sirt1^tm3Fwa
Tg(Nes-cre)1Kln/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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