|
Symbol Name ID |
Pik3ca
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha MGI:1206581 |
| Darker colors indicate more annotations |
| Human Phenotypes | Goiter |
Thyroid adenoma |
Thyroiditis |
Hyperthyroidism |
Hypothyroidism |
| Disease(s) Associated with PIK3CA | |||||
| Cowden syndrome 5 |
| Mouse Phenotypes | increased mammary gland epithelial cell proliferation |
increased pancreatic beta cell number |
abnormal branching of the mammary ductal tree |
abnormal mammary gland epithelium morphology |
abnormal mammary gland duct morphology |
abnormal mammary duct terminal end bud morphology |
abnormal mammary gland myoepithelium morphology |
abnormal mammary gland stroma morphology |
increased mammary gland tumor incidence |
increased fibroadenoma incidence |
increased mammary adenocarcinoma incidence |
increased mammary adenoacanthoma incidence |
increased pancreas weight |
enlarged pancreas |
pancreatic acinar-to-ductal metaplasia |
abnormal ovary morphology |
abnormal ovarian follicle number |
decreased testis weight |
increased pancreatic ductal adenocarcinoma incidence |
increased pancreatic intraepithelial neoplasia incidence |
increased prostate intraepithelial neoplasia incidence |
abnormal testis physiology |
|
| Availability | Mouse Genotype | ||||||||||||||||||||||
| Pik3catm1Bvan/Pik3ca+ | |||||||||||||||||||||||
| Tg(Amhr2-Pik3ca*,-GFP)#Lzh/0 | |||||||||||||||||||||||
| Pik3catm1.1Rzl/Pik3catm1.1Rzl Tg(Fabp4-cre)1Blw/0 (conditional) |
|||||||||||||||||||||||
| Pik3catm1Jjz/Pik3catm1Jjz Tg(Pbsn-cre)4Prb/0 (conditional) |
|||||||||||||||||||||||
| Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan/Gt(ROSA)26Sor+ Tg(MMTV-cre)1Mam/0 (conditional) |
|||||||||||||||||||||||
| Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan/Gt(ROSA)26Sor+ Tg(MMTV-cre)#Tfln/0 (conditional) |
|||||||||||||||||||||||
| Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan/Gt(ROSA)26Sor+ (conditional) | |||||||||||||||||||||||
| Gt(ROSA)26Sortm2(Pik3ca*)Dsa/Gt(ROSA)26Sor+ Ptf1atm1(cre)Hnak/Ptf1a+ (conditional) |
|||||||||||||||||||||||
| Gt(ROSA)26Sortm2(Pik3ca*)Dsa/Gt(ROSA)26Sor+ Tg(Cela1-cre/ERT)1Dam/0 (conditional) |
|||||||||||||||||||||||
| Pik3catm1.1Waph/Pik3ca+ (conditional) | |||||||||||||||||||||||
| Pik3catm1.1Waph/Pik3ca+ Tg(MMTV-cre)#Mam/0 (conditional) |
|||||||||||||||||||||||
| Pik3catm1Gne/Pik3ca+ Tg(MMTV-cre)1Mam/0 (conditional) |
|||||||||||||||||||||||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
|
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 05/14/2024 MGI 6.23 |
|
|
|
||
Analysis Tools