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Symbol
Name
ID
Pten
phosphatase and tensin homolog
MGI:109583
Phenotype annotations related to endocrine/exocrine glands
*Aspects of the system are reported to show a normal phenotype.
!Indicates phenotype varies with strain background.
Darker colors indicate more annotations
Human Phenotypes
Neoplasm of the adrenal cortex
Goiter
Thyroid adenoma
Hurthle cell thyroid adenoma
Thyroid carcinoma
Thyroiditis
Hashimoto thyroiditis
Hyperthyroidism
Hypothyroidism
Disease(s) Associated with PTEN
Bannayan-Riley-Ruvalcaba syndrome
macrocephaly-autism syndrome

Mouse Phenotypes
decreased granulosa cell apoptosis
impaired luteal cell differentiation
increased granulosa cell proliferation
increased pancreatic beta cell proliferation
abnormal exocrine pancreas morphology
abnormal pancreatic acinus morphology
abnormal centroacinar cell of Langerhans morphology
abnormal pancreatic acinar cell morphology
increased pancreatic acinar cell number
abnormal small intestine crypts of Lieberkuhn morphology
abnormal Paneth cell morphology
abnormal salivary gland morphology
decreased uterine NK cell number
endocrine/exocrine gland phenotype
bile duct hyperplasia
abnormal pancreatic beta cell morphology
increased pancreatic beta cell mass
increased pancreatic beta cell number
increased pancreatic islet number
enlarged pancreatic islets
pancreatic islet hyperplasia
increased solitary pulmonary neuroendocrine cell number
enlarged thymus
abnormal thyroid gland morphology
abnormal thyroid follicle morphology
abnormal thyroid follicular cell morphology
enlarged thyroid gland
thyroid gland hyperplasia
abnormal branching of the mammary ductal tree
abnormal involution of the mammary gland
abnormal mammary gland growth during pregnancy
abnormal mammary gland epithelium morphology
mammary gland duct hyperplasia
abnormal mammary gland lobule morphology
abnormal nipple morphology
increased mammary gland tumor incidence
increased fibroadenoma incidence
increased mammary adenocarcinoma incidence
increased mammary adenoacanthoma incidence
increased mammary gland tumor incidence in breeding females
mammary gland hyperplasia
abnormal prostate gland morphology
enlarged prostate gland anterior lobe
prostate gland anterior lobe hyperplasia
prostate gland dorsolateral lobe hyperplasia
abnormal prostate gland epithelium morphology
prostate gland epithelial hyperplasia
increased prostate gland weight
enlarged prostate gland
prostate gland hyperplasia
abnormal seminal vesicle morphology
abnormal corpus luteum morphology
increased corpora lutea number
abnormal ovarian follicle morphology
decreased primordial ovarian follicle number
absent primordial ovarian follicles
abnormal ovarian folliculogenesis
abnormal primordial ovarian follicle morphology
enlarged ovary
abnormal seminiferous tubule morphology
increased adrenal gland tumor incidence
increased pheochromocytoma incidence
increased granulosa cell tumor incidence
increased pancreatic ductal adenocarcinoma incidence
increased pancreatic intraepithelial neoplasia incidence
increased prostate gland tumor incidence
increased prostate gland adenocarcinoma incidence
increased prostate intraepithelial neoplasia incidence
increased T cell derived lymphoma incidence
increased thyroid tumor incidence
increased thyroid adenoma incidence
increased thyroid carcinoma incidence
increased insulin secretion
abnormal prostate gland physiology
prostate gland inflammation
abnormal pancreas physiology
abnormal ovary physiology
premature ovarian failure
Availability Mouse Genotype
Ptentm1.1Gle/Pten+
Ptentm1.1Hwu/Pten+
Ptentm1.1Mro/Pten+
Ptentm1.2Mwst/Pten+
Ptentm1Mak/Pten+
Ptentm1Ppp/Ptentm2Ppp
Ptentm1Rps/Pten+
Ptentm2.1Gle/Pten+
Ptentm1.1Mwst/Ptentm1.1Mwst
Tg(S100a4-cre)1Gle/0  (conditional)
Ptentm1.1Mwst/Ptentm1.1Mwst
Tg(TPO-cre)1Shk/0  (conditional)
Ptentm1Hwu/Ptentm1Hwu
Tg(KRT14-cre)#Smr/0  (conditional)
Nkx3-1tm4(cre/ERT2)Mms/Nkx3-1+
Ptentm1Hwu/Ptentm1Hwu  (conditional)
Ptentm1Hwu/Ptentm1Hwu
Tg(Pbsn-cre)4Prb/0  (conditional)
Ptentm1Hwu/Ptentm1Hwu
Tg(MMTV-cre)4Mam/0  (conditional)
Ptentm1Hwu/Ptentm1Hwu
Tg(Pdx1-cre)89.1Dam/0  (conditional)
Ptentm1Hwu/Ptentm1Hwu
Tg(Pdx1-cre/Esr1*)35.10Dam/0  (conditional)
Ptentm1Hwu/Ptentm1Hwu
Tg(CAG-Bgeo/ALPP)1Lbe/0
Tg(Cela1-cre/ERT)1Dam/0  (conditional)
*
Ptentm1Hwu/Ptentm1Hwu
Tg(Mx1-cre)1Cgn/0  (conditional)
Ptentm1Hwu/Ptentm1Hwu
Cnptm1(cre)Kan/Cnp+  (conditional)
Ptentm1Hwu/Ptentm1Hwu
Tg(Alb1-cre)1Dlr/0  (conditional)
Ptentm1Hwu/Ptentm1Hwu
Tg(Cdh16-cre)91Igr/0  (conditional)
Ptentm1Hwu/Ptentm1Hwu
Tg(Cdh5-cre)7Mlia/0  (conditional)
Ptentm1Hwu/Ptentm1Hwu
Tg(Fabp1-cre)1Jig/0  (conditional)
Ptentm1Hwu/Ptentm1Hwu
Tg(CYP19A1-cre)1Jri/0  (conditional)
Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+
Ptentm1Hwu/Ptentm1Hwu  (conditional)
Ptentm1Hwu/Ptentm1Hwu  (conditional)
Ptentm1Hwu/Ptentm1Hwu
Tg(Gdf9-icre)5092Coo/0  (conditional)
Ptentm1Hwu/Ptentm1Hwu
Tg(SFTPC-rtTA)5Jaw/0
Tg(tetO-cre)1Jaw/0  (conditional)
Ptentm1Hwu/Ptentm1Hwu
Tg(Ddx4-cre)1Dcas/0  (conditional)
Ptentm1Hwu/Ptentm1Hwu
Tg(Ddx4-cre/ERT2)1Dcas/0  (conditional)
Ptentm1Hwu/Ptentm1Hwu
Tg(Gdf9-icre)5092Coo/?  (conditional)
Ptentm1Hwu/Ptentm1Hwu
Tg(Vil1-cre)997Gum/0  (conditional)
Ptentm1Hwu/Ptentm1Hwu
Amhr2tm3(cre)Bhr/Amhr2+  (conditional)
Ptentm1Hwu/Ptentm1Hwu
Tg(Ins2-cre)25Mgn/0  (conditional)
Amhr2tm3(cre)Bhr/Amhr2+
Ptentm1Hwu/Ptentm1Hwu  (conditional)
Ptentm1Hwu/Ptentm1Hwu
Tg(Nkx2-1-cre)2Sand/0  (conditional)
! !
Ptentm1Hwu/Ptentm1Hwu
Tg(TPO-cre)1Shk/0  (conditional)
Ptentm1Hwu/Ptentm1Hwu
Tg(MMTV-cre)#Tfln/0  (conditional)
Ptentm1Hwu/Ptentm1Hwu
Tg(CD2-icre)4Kio/0  (conditional)
Ptentm1Hwu/Ptentm1Hwu
Tg(Pbsn-cre)20Fwan/?  (conditional)
Ptentm1Hwu/Ptentm1Hwu
Tg(Pgc-cre,-secNluc)#Hcz/0  (conditional)
Ptentm1Mro/Ptentm1Mro
Tg(KLK3-cre)D4Trp/0  (conditional)
Ptentm2.1Ppp/Ptentm2.1Ppp
Tg(Pbsn-cre)4Prb/0  (conditional)
Ptentm2.1Ppp/Ptentm2.1Ppp
Tg(Pbsn-cre)8113ANg/0  (conditional)
Ptentm2.1Ppp/Ptentm2.1Ppp
Tg(TPO-cre)1Shk/0  (conditional)
Ptentm2.1Ppp/Ptentm2.1Ppp
Tg(Osr1-cre)4Mrt/0  (conditional)
Hprt1tm1(Pbsn*-cre/ERT2)Jir/Y
Ptentm2Mak/Ptentm2Mak  (conditional)
Ptentm2Mak/Ptentm2Mak
Tg(KLK3-cre)13Saa/0  (conditional)
Ptentm2Mak/Ptentm2Mak
Tg(MMTV-cre)#Tfln/0  (conditional)
Ptentm2Mak/Ptentm2Mak
Tg(Wap-cre)11738Mam/0  (conditional)
Ptentm1Hwu/Pten+
Tg(KRT14-cre)#Smr/0  (conditional)
Ptentm1Hwu/Pten+
Tg(Pbsn-cre)4Prb/0  (conditional)
Ptentm1Hwu/Pten+
Tg(Nkx2-1-cre)2Sand/0  (conditional)
Ptentm1Mro/Pten+
Tg(KLK3-cre)D4Trp/0  (conditional)
Ptentm1Mro/Pten+
Tg(Pbsn-cre)4Prb/0  (conditional)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/14/2024
MGI 6.23
The Jackson Laboratory