Symbol
Name
ID

Prop1
paired like homeodomain factor 1
MGI:109330

Phenotype annotations related to endocrine/exocrine glands

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes

Abnormal circulating adrenocorticotropin concentration

Decreased circulating ACTH concentration

Decreased circulating follicle stimulating hormone concentration

Decreased circulating luteinizing hormone level

Decreased circulating free T3

Decreased circulating free T4 concentration

Reduced circulating growth hormone concentration

Decreased thyroid-stimulating hormone level

Impaired growth-hormone response to insulin stimulation test

Decreased response to growth hormone stimulation test

Adrenal insufficiency

Ectopic posterior pituitary

Posterior pituitary hypoplasia

Anterior pituitary agenesis

Anterior pituitary hypoplasia

Ectopic anterior pituitary gland

Hypopituitarism

Anterior hypopituitarism

Abnormal prolactin level

Reduced circulating prolactin concentration

Gonadotropin deficiency

Panhypopituitarism

Pituitary hypothyroidism

Reduced TSH response to thyrotrophin-releasing hormone stimulation test

Hypothyroidism

Absence of secondary sex characteristics

Delayed puberty

Hypogonadism

Hypogonadotropic hypogonadism

Male hypogonadism

Disease(s) Associated with PROP1

hypogonadism

hypopituitarism

panhypopituitarism

Mouse Phenotypes

endocrine/exocrine gland phenotype

abnormal pituitary gland morphology

abnormal adenohypophysis development

absent somatotrophs

decreased thyrotroph cell number

small adenohypophysis

adenohypophysis hypoplasia

abnormal neurohypophysis morphology

abnormal pituitary gland development

pituitary gland hypoplasia

small thyroid gland

absent corpus luteum

abnormal ovarian follicle morphology

abnormal granulosa cell morphology

decreased primary ovarian follicle number

increased primordial ovarian follicle number

decreased secondary ovarian follicle number

decreased tertiary ovarian follicle number

absent tertiary ovarian follicles

small ovary

hypopituitarism

Availability

Mouse Genotype

Prop1^df/Prop1^df

Prop1^tm1Rsd/Prop1^tm1Rsd

Prop1^tm1Sac/Prop1^tm1Sac

Prop1^tm1Sac/Prop1⁺

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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