Symbol
Name
ID

Nkx2-1
NK2 homeobox 1
MGI:108067

Phenotype annotations related to endocrine/exocrine glands

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Goiter	Non-medullary thyroid carcinoma	Papillary thyroid carcinoma
Disease(s) Associated with NKX2-1
thyroid gland papillary carcinoma

Mouse Phenotypes

endocrine/exocrine gland phenotype

abnormal adrenal cortex morphology

abnormal adenohypophysis development

abnormal Rathke's pouch apoptosis

abnormal Rathke's pouch development

absent infundibular recess of third ventricle

absent pituitary infundibular stalk

abnormal pituitary gland development

absent pituitary gland

abnormal thyroid follicle morphology

abnormal thyroid gland development

absent thyroid gland

small thyroid gland

abnormal Leydig cell morphology

decreased testis weight

decreased testes secretion

Availability

Mouse Genotype

Nkx2-1^tm1Jaw/Nkx2-1^tm1Jaw

Nkx2-1^tm1Shk/Nkx2-1^tm1Shk

Nkx2-1^tm2Rdl/Nkx2-1^tm2Rdl

Nkx2-1^tm2Shk/Nkx2-1^tm2Shk

Nkx2-1^tm3Rdl/Nkx2-1^tm3Rdl

Nkx2-1^tm2Shk/Nkx2-1^tm2Shk
Tg(TPO-cre)1Shk/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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