Symbol
Name
ID

Kcnj11
potassium inwardly rectifying channel, subfamily J, member 11
MGI:107501

Phenotype annotations related to endocrine/exocrine glands

Darker colors indicate more annotations

Human Phenotypes	Maternal diabetes	Diabetes mellitus	Maturity-onset diabetes of the young	Type I diabetes mellitus	Type II diabetes mellitus	Hyperinsulinemic hypoglycemia	Nesidioblastosis	Pancreatic islet-cell hyperplasia
Disease(s) Associated with KCNJ11	Maternal diabetes	Diabetes mellitus	Maturity-onset diabetes of the young	Type I diabetes mellitus	Type II diabetes mellitus	Hyperinsulinemic hypoglycemia	Nesidioblastosis	Pancreatic islet-cell hyperplasia
familial hyperinsulinemic hypoglycemia 2
maturity-onset diabetes of the young type 13
permanent neonatal diabetes mellitus
type 2 diabetes mellitus

Mouse Phenotypes

abnormal pancreatic islet morphology

abnormal pancreatic alpha cell morphology

decreased pancreatic alpha cell number

increased pancreatic alpha cell number

abnormal pancreatic beta cell morphology

decreased pancreatic beta cell number

decreased pancreatic islet number

small pancreatic islets

abnormal pancreas morphology

decreased pancreas weight

decreased glucagon secretion

abnormal pancreatic beta cell physiology

decreased insulin secretion

increased insulin secretion

Availability

Mouse Genotype

Kcnj11^tm1Sse/Kcnj11^tm1Sse

Kcnj11^tm1Sse/Kcnj11^tm1Sse
Tg(Ins1-Kcnj11*)#Nich/?

Kcnj11^Y12stop/Kcnj11^Y12stop

Kcnj11^tm1Sse/Kcnj11⁺
Tg(Ins1-Kcnj11*)#Nich/?

Tg(Ins1-Kcnj11*)#Nich/?

Gt(ROSA)26Sor^{tm1(CAG-Kcnj11*,-GFP)Nich}/Gt(ROSA)26Sor⁺
Tg(Ins2-cre)23Herr/0 (conditional)

Gt(ROSA)26Sor^{tm1(Kcnj11*V59M)Fmas}/Gt(ROSA)26Sor⁺
Tg(Ins2-cre)23Herr/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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