|
Symbol Name ID |
Bmp4
bone morphogenetic protein 4 MGI:88180 |
| Darker colors indicate more annotations |
| Human Phenotypes | Sparse scalp hair |
Brachycephaly |
Lambdoidal craniosynostosis |
Plagiocephaly |
Micrognathia |
Retrognathia |
Aplasia of the maxilla |
Small sella turcica |
Microcephaly |
Facial asymmetry |
Short face |
Midface retrusion |
High forehead |
Cleft lip |
Eclabion |
Bifid uvula |
Cleft palate |
High palate |
Microglossia |
Abnormal dental morphology |
Short dental root |
Taurodontia |
Peg-shaped maxillary lateral incisors |
Abnormal primary molar morphology |
Microdontia |
Agenesis of central incisor |
Agenesis of lateral incisor |
Agenesis of maxillary lateral incisor |
Agenesis of permanent teeth |
Tooth agenesis |
Anodontia |
Hypodontia |
Oligodontia |
Oligodontia of primary teeth |
Selective tooth agenesis |
Agenesis of molar |
Agenesis of permanent molar |
Agenesis of first permanent molar tooth |
Agenesis of premolar |
Agenesis of mandibular premolar |
Abnormality of canine |
Delayed eruption of teeth |
Delayed eruption of permanent teeth |
Enamel hypoplasia |
Hypoplasia of teeth |
Abnormality of primary teeth |
Dental malocclusion |
Widely spaced teeth |
Orofacial cleft |
Impaired mastication |
Sparse eyebrow |
Short eyelashes |
Orbital cyst |
| Disease(s) Associated with BMP4 | |||||||||||||||||||||||||||||||||||||||||||||||||||||
| orofacial cleft 11 | |||||||||||||||||||||||||||||||||||||||||||||||||||||
| syndromic microphthalmia 6 | |||||||||||||||||||||||||||||||||||||||||||||||||||||
| tooth agenesis |
| Mouse Phenotypes | abnormal pharyngeal arch artery morphology |
large anterior fontanelle |
frontal bone hypoplasia |
short frontal bone |
small interparietal bone |
abnormal jaw morphology |
abnormal mandible morphology |
absent mandibular angle |
absent mandibular condyloid process |
absent mandibular coronoid process |
abnormal temporomandibular joint morphology |
mandible hypoplasia |
maxilla hypoplasia |
agnathia |
retrognathia |
syngnathia |
nasal bone hypoplasia |
short nasal bone |
abnormal secondary palate development |
palatal shelves fail to meet at midline |
decreased palatal shelf size |
palatal shelf fusion with tongue or mandible |
abnormal face development |
cleft palate |
abnormal snout morphology |
short snout |
absent outer ear |
|
| Availability | Mouse Genotype | |||||||||||||||||||||||||||
| Bmp4tm1Blh/Bmp4+ | ||||||||||||||||||||||||||||
| Bmp4tm1Jfm/Bmp4tm1Jfm H2az2Tg(Wnt1-cre)11Rth/H2az2+ (conditional) |
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| Bmp4tm3Blh/Bmp4tm3Blh Foxg1tm1(cre)Skm/Foxg1+ (conditional) |
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| Bmp4tm1Jfm/Bmp4tm1.1Jfm Nkx2-5tm1(cre)Rjs/Nkx2-5+ (conditional) |
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| H2az2Tg(Wnt1-cre)11Rth/H2az2+ Tg(CAG-Bmp4,-EGFP)1Ypc/0 (conditional) |
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| Osr2tm2(cre)Jian/Osr2+ Tg(CAG-Bmp4,-EGFP)1Ypc/0 (conditional) |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/14/2024 MGI 6.23 |
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