Symbol
Name
ID

Fras1
Fraser extracellular matrix complex subunit 1
MGI:2385368

Phenotype annotations related to craniofacial

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes

Extension of hair growth on temples to lateral eyebrow

Calvarial skull defect

Microcephaly

Encephalocele

Facial asymmetry

Cleft upper lip

Cleft palate

Dental crowding

Dental malocclusion

Difficulty in tongue movements

Choanal stenosis

Cleft ala nasi

Underdeveloped nasal alae

Depressed nasal bridge

Wide nasal bridge

Midline nasal groove

Wide nose

Absent eyebrow

Absent eyelashes

Cryptophthalmos

Upper eyelid coloboma

Lacrimal duct aplasia

Malformed lacrimal duct

Tessier cleft

Disease(s) Associated with FRAS1

Fraser syndrome 1

Mouse Phenotypes		craniofacial phenotype	micrognathia	abnormal palatal shelf morphology	abnormal palatal shelf fusion at midline	cleft secondary palate	cleft palate	complete cleft palate
Availability	Mouse Genotype	craniofacial phenotype	micrognathia	abnormal palatal shelf morphology	abnormal palatal shelf fusion at midline	cleft secondary palate	cleft palate	complete cleft palate
	Fras1^b2b3323Clo/Fras1^b2b3323Clo
	Fras1^bfb/Fras1^bfb	*
	Fras1^rdf/Fras1^rdf

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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