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Symbol
Name
ID

Six1
sine oculis-related homeobox 1
MGI:102780

Phenotype annotations related to craniofacial

Darker colors indicate more annotations

Human Phenotypes	Preauricular pit
Disease(s) Associated with SIX1	Preauricular pit
autosomal dominant nonsyndromic deafness 23

Mouse Phenotypes

abnormal craniofacial morphology

abnormal craniofacial bone morphology

abnormal styloid process morphology

abnormal Meckel's cartilage morphology

abnormal frontal bone morphology

short temporal bone squamous part

abnormal hyoid bone greater horn morphology

short mandible

short maxilla

micrognathia

abnormal nasal bone morphology

absent turbinates

short zygomatic bone

abnormal incus morphology

absent incus

abnormal malleus morphology

abnormal stapes morphology

absent stapes

abnormal face development

abnormal midface morphology

abnormal genioglossus muscle morphology

decreased tongue size

abnormal nose morphology

abnormal external nares morphology

abnormal nasal cavity morphology

absent vomeronasal organ

abnormal olfactory epithelium morphology

absent olfactory epithelium

Availability

Mouse Genotype

Six1^Cwe/Six1^Cwe

Six1^em1(IMPC)Mbp/Six1^em1(IMPC)Mbp

Six1^tm1Kwk/Six1^tm1Kwk

Six1^tm1Mair/Six1^tm1Mair

Six1^tm1Rsd/Six1^tm1Rsd

Six1^tm1Mair/Six1⁺

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 05/21/2024 MGI 6.23