Symbol
Name
ID

Opa1
OPA1, mitochondrial dynamin like GTPase
MGI:1921393

Phenotype annotations related to cellular

Darker colors indicate more annotations

Human Phenotypes	Decreased activity of mitochondrial complex I	Decreased activity of mitochondrial complex IV
Disease(s) Associated with OPA1	Decreased activity of mitochondrial complex I	Decreased activity of mitochondrial complex IV
mitochondrial DNA depletion syndrome 14

Mouse Phenotypes

abnormal mitochondrial morphology

decreased muscle fiber mitochondrial DNA content

abnormal mitochondrial crista morphology

disorganized mitochondrial cristae

abnormal mitochondrial shape

decreased mitochondrial number

increased mitochondrial number

increased mitochondrial size

abnormal autophagy

abnormal mitophagy

decreased pancreatic beta cell proliferation

abnormal respiratory electron transport chain

abnormal mitochondrial physiology

Availability

Mouse Genotype

Opa1^lilr3/Opa1^lilr3

Opa1^Q285X/Opa1⁺

Opa1^tm1.1Geno/Opa1⁺

Hprt1^{tm1(ACTB-Opa1)Lsc}/Y

Opa1^tm1Lsc/Opa1^tm1Lsc (conditional)

Opa1^tm1.1Hise/Opa1^tm1.2Hise
Tg(Ins2-cre)25Mgn/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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