Symbol
Name
ID

Mad2l2
MAD2 mitotic arrest deficient-like 2
MGI:1919140

Phenotype annotations related to cellular

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Chromosomal breakage induced by crosslinking agents
Disease(s) Associated with MAD2L2	Chromosomal breakage induced by crosslinking agents
Fanconi anemia complementation group V

Mouse Phenotypes

cellular phenotype

decreased oocyte number

azoospermia

decreased male germ cell number

abnormal primordial germ cell morphology

decreased primordial germ cell number

absent primordial germ cells

absent germ cells

abnormal cell cycle

increased enterocyte apoptosis

abnormal primordial germ cell apoptosis

increased primordial germ cell apoptosis

increased forebrain apoptosis

abnormal oogenesis

abnormal primordial germ cell migration

decreased cell proliferation

abnormal epigenetic regulation of gene expression

abnormal double-strand DNA break repair

Availability

Mouse Genotype

Mad2l2^repro22/Mad2l2^repro22

Mad2l2^tm1.1Mpz/Mad2l2^tm1.1Mpz

Mad2l2^tm1Ymu/Mad2l2^tm1Ymu

Mad2l2^tm1Mpz/Mad2l2^tm1Mpz
Tg(Prdm1-cre)1Masu/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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